ArticleJournal of dental research2018
Hypercementosis Associated with ENPP1 Mutations and GACI.
Abstract readCase Reports
In one paragraph
Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Prevalence of Hypercementosis in Radiographic Studies: A Systematic Review and Meta-Analysis With Clinical Implications for Endodontic Assessment.International endodontic journal · 2026Pooled it
- Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Review
- Reduced orthodontic tooth movement inJBMR plus · 2025Article
- Effectiveness of Dental Restorative Materials in the Atraumatic Treatment of Carious Primary Teeth in Pediatric Dentistry: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Decoding dental mesenchymal stem cells diversity: single-cell transcriptomics maps heterogeneity in molar development.Frontiers in cell and developmental biology · 2025Review
- Cementum regeneration strategies: Insights from development and periodontal microenvironment.Frontiers in cell and developmental biology · 2025Review
- The Diagnosis and Management of Infraoccluded Deciduous Molars: A Systematic Review.Children (Basel, Switzerland) · 2024Review
- Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging.Journal of bone and mineral metabolism · 2024Article
- Inherited phosphate and pyrophosphate disorders: New insights and novel therapies changing the oral health landscape.Journal of the American Dental Association (1939) · 2024Review
- CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B.International journal of oral science · 2024Article
- Beyond dirty teeth: Integrating dental calculus studies with osteoarchaeological parameters.Quaternary international : the journal of the International Union for Quaternary Research · 2023Article
- Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity.Scientific reports · 2022Article
- ENPP1 deficiency: A clinical update on the relevance of individual variants using a locus-specific patient database.Human mutation · 2022Review
- Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Mutation update: Variants of the ENPP1 gene in pathologic calcification, hypophosphatemic rickets, and cutaneous hypopigmentation with punctate keratoderma.Human mutation · 2022Review
- Prevalence and Manifestations of Dental Ankylosis in Primary Molars Using Panoramic X-rays: A Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early-Onset Osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Article
- Cementocyte alterations associated with experimentally induced cellular cementum apposition in Hyp mice.Journal of periodontology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 2 countries.
V Thumbigere-Math1 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
A Alqadi3 Division of Public and Child Dental Health, Dublin Dental University Hospital, Dublin, Ireland.
N I Chalmers4 Analytics and Publication, DentaQuest Institute, Westborough, MA, USA.
M B Chavez5 Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
E Y Chu1 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
M T Collins6 Section on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
C R Ferreira7 National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
K FitzGerald3 Division of Public and Child Dental Health, Dublin Dental University Hospital, Dublin, Ireland.
R I Gafni6 Section on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
W A Gahl7 National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
K S Hsu7 National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, USA.
M S Ramnitz6 Section on Skeletal Disorders and Mineral Homeostasis, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
M J Somerman1 National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
S G Ziegler10 Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
B L Foster5 Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
National Institute of Dental and Craniofacial Research · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institutes of Health · USThe Ohio State University · USChildren's Health Ireland at Crumlin · IEDublin Dental University Hospital · IEJohns Hopkins University · USNational Human Genome Research Institute · USUniversity of Maryland, Baltimore · US
Funding
Human Biochemical GeneticsZIAHG000215 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GAHL, WILLIAM · 2009 to 2025
$72.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MSkeletal Disorders and Mineral Homeostasis SectionZIADE000649 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI COLLINS, MICHAEL · 2009 to 2025
$32.8MNIAMS Light Imaging FacilityZICAR041186 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI RANDAZZO, DAVIDE · 2010 to 2025
$18.2MClinical Research of Oral Connective Tissue ProgramZIAAR041197 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI SOMERMAN, MARTHA · 2013 to 2021
$1.6MExtracellular Matrix and Phosphate/Pyrophosphate Metabolism in Cementum FormationR00AR066110 · NIAMS · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2015 to 2017
$747kNIAMS NIH HHS R00 AR066110NIGMS NIH HHS T32 GM007309
Abstract
Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (P
Indexed as
Loss of Function MutationAdultAnimalsChildFemaleGenotypeHumansHypercementosisMaleMicePedigreePhosphoric Diester HydrolasesPyrophosphatasesRadiography, PanoramicTooth, DeciduousVascular Calcificationectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatasescementumenamelgeneralized arterial calcification of infancymineralized tissue/developmentperiodontal tissues/developmenttooth development
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.