ArticlePloS one2017
Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Extremophiles and Extremophilic Behaviour-New Insights and Perspectives.Life (Basel, Switzerland) · 2024Review
- Stress-induced nucleoid remodeling in Deinococcus radiodurans is associated with major changes in Heat Unstable (HU) protein dynamics.Nucleic acids research · 2024Article
- The Impacts of Microgravity on Bacterial Metabolism.Life (Basel, Switzerland) · 2022Review
- Thiol Reductases inAntioxidants (Basel, Switzerland) · 2022Review
- Comprehensive Temporal Protein Dynamics during Postirradiation Recovery inOxidative medicine and cellular longevity · 2022Article
- Proteomic Response ofLife (Basel, Switzerland) · 2021Article
- Response ofPeerJ · 2021Article
- Molecular repertoire of Deinococcus radiodurans after 1 year of exposure outside the International Space Station within the Tanpopo mission.Microbiome · 2020Article
- Ionizing Radiation-induced Proteomic Oxidation inMolecular & cellular proteomics : MCP · 2020Article
- Molecular Mechanisms of Microbial Survivability in Outer Space: A Systems Biology Approach.Frontiers in microbiology · 2020Review
- Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach.Scientific reports · 2019Article
- CRISPR-mediated gene silencing reveals involvement of the archaeal S-layer in cell division and virus infection.Nature communications · 2019Article
- Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems.PloS one · 2019Article
- Proteomic and Metabolomic Profiling ofFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D. radiodurans after the exposure to space-related conditions of UVC irradiation and vacuum. Notably, scanning electron microscopy investigations showed that neither morphology nor cellular integrity of irradiated cells was affected, while integrated proteomic and metabolomic analysis revealed numerous molecular alterations in metabolic and stress response pathways. Several molecular key mechanisms of D. radiodurans, including the tricarboxylic acid cycle, the DNA damage response systems, ROS scavenging systems and transcriptional regulators responded in order to cope with the stressful situation caused by UVC irradiation under vacuum conditions. These results reveal the effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors.
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