ArticlePloS one2017
Surface-modified nanoparticles as anti-biofilm filler for dental polymers.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Quaternary Ammonium Silica Nanoparticles for Antimicrobial Implantable Medical Devices: An In Vitro Study.Life (Basel, Switzerland) · 2024Article
- Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters.Materials (Basel, Switzerland) · 2024Article
- PLA Nanofibers for Microenvironmental-Responsive Quercetin Release in Local Periodontal Treatment.Molecules (Basel, Switzerland) · 2022Article
- Review
- Ionic liquid-loaded microcapsules doped into dental resin infiltrants.Bioactive materials · 2021Article
- Demineralization prevention with a new antibacterial restorative composite containing QASi nanoparticles: an in situ study.Clinical oral investigations · 2021Article
- Review
- The salivary pellicle on dental biomaterials.Colloids and surfaces. B, Biointerfaces · 2021Review
- Article
- Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Review
- Testing Anti-Biofilm Polymeric Surfaces: Where to Start?International journal of molecular sciences · 2019Review
- Functional assessment of peptide-modified PLGA nanoparticles against oral biofilms in a murine model of periodontitis.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- BAR-encapsulated nanoparticles for the inhibition and disruption of Porphyromonas gingivalis-Streptococcus gordonii biofilms.Journal of nanobiotechnology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the study was to synthesis silica nanoparticles modified with (i) a tertiary amine bearing two t-cinnamaldehyde substituents or (ii) dimethyl-octyl ammonium, alongside the well-studied quaternary ammonium polyethyleneimine nanoparticles. These were to be evaluated for their chemical and mechanical properties, as well for antibacterial and antibiofilm activity. Samples were incorporated in commercial dental resin material and the degree of monomer conversion, mechanical strength, and water contact angle were tested to characterize the effect of the nanoparticles on resin material. Antibacterial activity was evaluated with the direct contact test and the biofilm inhibition test against Streptococcus mutans. Addition of cinnamaldehyde-modified particles preserved the degree of conversion and compressive strength of the base material and increased surface hydrophobicity. Quaternary ammonium functional groups led to a decrease in the degree of conversion and to low compressive strength, without altering the hydrophilic nature of the base material. In the direct contact test and the anti-biofilm test, the polyethyleneimine particles exhibited the strongest antibacterial effect. The cinnamaldehyde-modified particles displayed antibiofilm activity, silica particles with quaternary ammonium were ineffective. Immobilization of t-cinnamaldehyde onto a solid surface via amine linkers provided a better alternative to the well-known quaternary ammonium bactericides.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.