ArticlePLoS computational biology2017
Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- In Vitro Model of Vascular Remodeling Under Microfluidic Perfusion.Micromachines · 2024Article
- Hemodynamic regulation allows stable growth of microvascular networks.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration.PLoS computational biology · 2023Article
- Red blood cell lingering modulates hematocrit distribution in the microcirculation.Biophysical journal · 2023Article
- Vein fate determined by flow-based but time-delayed integration of network architecture.eLife · 2023Article
- Red blood cell dynamics in extravascular biological tissues modelled as canonical disordered porous media.Interface focus · 2022Article
- Computational simulations of the 4D micro-circulatory network in zebrafish tail amputation and regeneration.Journal of the Royal Society, Interface · 2022Article
- Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network.Frontiers in cardiovascular medicine · 2022Article
- Control of low flow regions in the cortical vasculature determines optimal arterio-venous ratios.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fluid flows shaping organism morphology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Flow rate of transport network controls uniform metabolite supply to tissue.Journal of the Royal Society, Interface · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the trunk act together to uniformly partition red blood cells through the microvasculature. Using mathematical models as well as direct observation, we show that these occlusive feedbacks are tuned throughout the trunk network to prevent the vessels closest to the heart from short-circuiting the network. Thus occlusion is linked with another open question of microvascular function: how are red blood cells delivered at the same rate to each micro-vessel? Our analysis shows that tuning of occlusive feedbacks increase the total dissipation within the network by a factor of 11, showing that uniformity of flows rather than minimization of transport costs may be prioritized by the microvascular network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.