ArticlePediatric research2018
Amplitude-integrated electroencephalography during the first 72 h after birth in neonates diagnosed prenatally with congenital heart disease.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Spectral EEG in Congenital Heart Disease: A Case-Control Study in Infants Undergoing Cardiac Surgery.Pediatric cardiology · 2026Article
- Seizures in congenital heart disease: risks, outcomes, and birth cohort data from China.Frontiers in pediatrics · 2026Article
- The impact of sleep in high-risk infants.Pediatric research · 2025Review
- Digital neonatal neurocritical care in Brazil: a retrospective multicentre cohort study of over 11,000 remotely monitored infants.Lancet regional health. Americas · 2025Article
- Neuromonitoring practices for neonates with congenital heart disease: a scoping review.Pediatric research · 2025Article
- Neonatal Seizures: New Evidence, Classification, and Guidelines.Epilepsy currents · 2024Review
- Continuous electroencephalography (cEEG) in infants with congenital heart disease (CHD).Pediatric research · 2023Article
- Article
- Article
- The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care.Pediatric neurology · 2020Review
- Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease.Current opinion in pediatrics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundLittle is known on amplitude-integrated electroencephalography (aEEG) during the first few days after birth in neonates with congenital heart disease (CHD). Our aim was, therefore, to assess electrocortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG.MethodsNeonates with CHD who were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included. We assessed aEEG background patterns, sleep-wake cycling, and epileptic activity during the first 72 h after birth and defined prenatal and postnatal clinical parameters associated with aEEG patterns.ResultsSeventy-two neonates were included. Twenty-six (36%) had mildly abnormal and six (8%) had severely abnormal aEEG background patterns at some point during the study period. Sleep-wake cycling was present in 97% of the neonates. Subclinical seizures were common (15%), whereas none of the neonates had clinical seizures. Only treatment with sedatives was a significant predictor for abnormal aEEG background patterns, explaining 56% of the variance.ConclusionAbnormal aEEG background patterns are common and are strongly associated with treatment with sedatives in neonates with prenatally diagnosed CHD. Future studies should assess the association between early postnatal aEEG abnormalities and neurodevelopmental outcome.
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