ArticleAmerican journal of respiratory and critical care medicine2018
Pulmonary Vasodilator Therapy in Shock-associated Cardiac Arrest.
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial.Resuscitation · 2023Trial
- Trial
- Wolf Creek XVII part 9: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.Resuscitation plus · 2024Review
- The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes.Critical care (London, England) · 2023Article
- Nitric oxide: Clinical applications in critically ill patients.Nitric oxide : biology and chemistry · 2022Review
- Nitric oxide delivery using nitric oxide-containing fluid in continuous hemofiltration: an in vitro study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Pulmonary hypertension among children with in-hospital cardiac arrest: A multicenter study.Resuscitation · 2021Article
- A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation.Resuscitation · 2021Article
- MLWAVE: A novel algorithm to classify primary versus secondary asphyxia-associated ventricular fibrillation.Resuscitation plus · 2021Article
- The physiologic response to rescue therapy with vasopressin versus epinephrine during experimental pediatric cardiac arrest.Resuscitation plus · 2020Article
- Epinephrine's effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation.Critical care (London, England) · 2020Article
- Prevalence and Outcomes of Pediatric In-Hospital Cardiac Arrest Associated With Pulmonary Hypertension.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Article
- Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments.Frontiers in medicine · 2020Review
- Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes.Critical care medicine · 2019Observational
- Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest-the PERSEUS resuscitation protocol.Heart failure reviews · 2019Review
- Update in Critical Care and Acute Respiratory Distress Syndrome 2018.American journal of respiratory and critical care medicine · 2019Article
- Can a Physiologic Insight "Resuscitate" Research in Cardiopulmonary Resuscitation?American journal of respiratory and critical care medicine · 2019Article
- Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes.Resuscitation · 2018Observational
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleMany in-hospital cardiac arrests are precipitated by hypotension, often associated with systemic inflammation. These patients are less likely to be successfully resuscitated, and novel approaches to their treatment are needed.
objectivesTo determine if the addition of inhaled nitric oxide (iNO) to hemodynamic-directed cardiopulmonary resuscitation (HD-CPR) would improve short-term survival from cardiac arrest associated with shock and systemic inflammation.
methodsIn 3-month-old swine (n = 21), LPS was intravenously infused, inducing systemic hypotension. Ventricular fibrillation was induced, and animals were randomized to blinded treatment with either: 1) HD-CPR with iNO, or 2) HD-CPR without iNO. During HD-CPR, chest compression depth was titrated to peak aortic compression pressure of 100 mm Hg, and vasopressor administration was titrated to coronary perfusion pressure greater than or equal to 20 mm Hg. Defibrillation attempts began after 10 minutes of resuscitation. The primary outcome was 45-minute survival. MEASUREMENTS AND MAIN
resultsThe iNO group had higher rates of 45-minute survival (10 of 10 vs. 3 of 11; P = 0.001). During cardiopulmonary resuscitation, the iNO group had lower pulmonary artery relaxation pressure (mean ± SEM, 10.9 ± 2.4 vs. 18.4 ± 2.4 mm Hg; P = 0.03), higher coronary perfusion pressure (21.1 ± 1.5 vs. 16.9 ± 1.0 mm Hg; P = 0.005), and higher aortic relaxation pressure (36.6 ± 1.6 vs. 30.4 ± 1.1 mm Hg; P < 0.001) despite shallower chest compressions (5.88 ± 0.25 vs. 6.46 ± 0.40 cm; P = 0.02) and fewer vasopressor doses in the first 10 minutes (median, 4 [interquartile range, 3-4] vs. 5 [interquartile range, 5-6], P = 0.03).
conclusionsThe addition of iNO to HD-CPR in LPS-induced shock-associated cardiac arrest improved short-term survival and intraarrest hemodynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.