Evidence map›Paper›PMID 29244251›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Effect of Combination Folic Acid, Vitamin B

Katie L Stone, Li-Yung Lui, William G Christen, Aron M Troen, Douglas C Bauer, Deborah Kado, Christopher Schambach, Steven R Cummings, JoAnn E Manson

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  3. A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Trial
  4. Trial
  5. Review
  6. Role of vitamins in the development and treatment of osteoporosis (Review).International journal of molecular medicine · 2025
    Review
  7. Gut-X axis.iMeta · 2025
    Review
  8. Article
  9. Article
  10. Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Observational
  17. Nutritional Supplements and Skeletal Health.Current osteoporosis reports · 2021
    Review
  18. Review
  19. Article
  20. Insufficiency of B vitamins with its possible clinical implications.Journal of clinical biochemistry and nutrition · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Katie L StoneResearch Institute, California Pacific Medical Center, San Francisco, CA, USA.
Li-Yung LuiResearch Institute, California Pacific Medical Center, San Francisco, CA, USA.
William G ChristenDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aron M TroenVitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture (USDA) Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Douglas C BauerDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Deborah KadoDepartment of Family Medicine & Public Health, University of California, San Diego, San Diego, CA, USA.
Christopher SchambachResearch Institute, California Pacific Medical Center, San Francisco, CA, USA.
Steven R CummingsResearch Institute, California Pacific Medical Center, San Francisco, CA, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
California Pacific Medical Center · USHarvard University · USUniversity of California, San Francisco · USSmith Institute · GBUniversity of California System · US

Funding

TRIAL OF ANTIOXIDANT THERAPY OF CVD IN WOMENR01HL046959 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MANSON, JOANN ELISABETH · 1993 to 2005
$3.6M
Folic Acid and B Vitamins to Prevent Fracture in WomenR01AR052817 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2006 to 2009
$1.7M
NHLBI NIH HHS R01 HL046959NIAMS NIH HHS R01 AR052817
6 · The paper itself

Abstract

Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B

Indexed as

Dietary SupplementsAgedBiomarkersBone RemodelingCohort StudiesFemaleFolic AcidFollow-Up StudiesFractures, BoneHomocysteineHumansIncidenceMiddle AgedRisk FactorsTreatment OutcomeVitamin B 12BiomarkersFolic AcidHomocysteineVitamin B 12Vitamin B 6BIOCHEMICAL MARKERS OF BONE TURNOVERB VITAMINSFRACTURE PREVENTIONNUTRITIONOSTEOPOROSISTHERAPEUTICS

Identifiers

PMID29244251
PMCPMC5734110
OpenAlexW2741462459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.