ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Prevalence and Risk of Severe Cognitive Impairment in Advanced Chronic Kidney Disease.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Kidney function and cognitive impairment: a systematic review and meta-analysis.Renal failure · 2025Pooled it
- Prevalence of cognitive impairment and its predictors among chronic kidney disease patients: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Review
- Trends in Co-morbid Dementia and Chronic Kidney Disease.Journal of general internal medicine · 2025Article
- Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results.Alzheimer's research & therapy · 2025Article
- Kidney replacement therapies in the older person: challenges to decide the best option.Clinical kidney journal · 2025Review
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2024Article
- Common mental disorders and associated factors among adult chronic kidney disease patients attending referral hospitals in Amhara Regional State.Scientific reports · 2024Article
- Current Status of the Cognitive Impairment in Chronic Kidney Disease.Physical therapy research · 2024Review
- Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage.Current medical science · 2023Article
- Kidney Disease and Brain Health: Current Knowledge and Next Steps.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- The Association of Kidney Function with Plasma Amyloid-β Levels and Brain Amyloid Deposition.Journal of Alzheimer's disease : JAD · 2023Article
- Frailty and Age-Associated Assessments Associated with Chronic Kidney Disease and Transplantation Outcomes.Journal of transplantation · 2023Review
- Chronic kidney disease, physical activity and cognitive function in older adults-results from the National Health and Nutrition Examination Survey (2011-2014).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Mild to moderate decrease in eGFR and cognitive decline in older adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Cognitive impairment, perceived medication adherence, and high-risk medication use in patients with reduced kidney function: A cross-sectional analysis.Health science reports · 2022Article
- Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Emotional and cognitive changes in chronic kidney disease.The Korean journal of internal medicine · 2022Review
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Background: Our primary goal is to describe the prevalence, severity, and risk of cognitive impairment (CI) by estimated glomerular filtration rate (eGFR, in mL/min/1.73 m2) in a cohort enriched for advanced chronic kidney disease (CKD; eGFR < 45), adjusting for albuminuria, as measured by urine albumin-to-creatinine ratio (UACR, in mg/g). As both eGFR and albuminuria are associated with CI risk in CKD, we also seek to determine the extent that eGFR remains a useful biomarker for risk of CI in those with CKD and concomitant albuminuria. Methods: Chi-square tests measured the prevalence of severe CI and mild cognitive impairment (MCI) by eGFR level. Logistic regression models and generalized linear models measured risk of CI by eGFR, adjusted for UACR. Results: Participants were 574 adults with a mean age of 69; 433 with CKD (eGFR < 60, nondialysis) and 141 controls (eGFR ≥ 60). Forty-eight percent of participants with CKD had severe CI or MCI. The prevalence of severe CI was highest (25%) in those with eGFR < 30. eGFR < 30 was only associated with severe CI in those without albuminuria (UACR < 30; OR = 3.3; p = .02) and was not associated with MCI in similar models. Conclusions: One quarter of those with eGFR < 30 had severe CI. eGFR < 30 was associated with over threefold increased odds of severe CI in those with UACR < 30, but not with UACR > 30, suggesting that eGFR < 30 is a valid biomarker for increased risk of severe CI in those without concomitant albuminuria.
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Registered trials
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