Evidence map›Paper›PMID 29244054›Full record

SynthesisArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2018

A Systematic Review for Functional Neuroimaging Studies of Cognitive Reserve Across the Cognitive Aging Spectrum.

Mia Anthony, Feng Lin

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Electroencephalography, Magnetoencephalography, and Cognitive Reserve: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021
    Pooled it
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  6. Cognitive reserve and everyday functioning in cognitively unimpaired older adults: evidence from the CAN-PROTECT study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  14. Observational
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  20. Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mia AnthonySchool of Nursing, University of Rochester Medical Center, Rochester, NY 14642, USA.
Feng LinSchool of Nursing, University of Rochester Medical Center, Rochester, NY 14642, USA.

Funding

Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive ImpairmentR01NR015452 · NINR · UNIVERSITY OF ROCHESTER · PI HEFFNER, KATHI L, LIN, FENG VANKEE · 2015 to 2024
$4.4M
Applying the Neuroeconomics Paradigm for the Assessment of Central Fatigability in the Aging PopulationR21AG053193 · NIA · UNIVERSITY OF ROCHESTER · PI LIN, FENG VANKEE · 2016 to 2017
$421k
NIA NIH HHS R21 AG053193NINR NIH HHS R01 NR015452
6 · The paper itself

Abstract

objectiveCognitive reserve has been proposed to explain the discrepancy between clinical symptoms and the effects of aging or Alzheimer's pathology. Functional magnetic resonance imaging (fMRI) may help elucidate how neural reserve and compensation delay cognitive decline and identify brain regions associated with cognitive reserve. This systematic review evaluated neural correlates of cognitive reserve via fMRI (resting-state and task-related) studies across the cognitive aging spectrum (i.e., normal cognition, mild cognitive impairment, and Alzheimer's disease).

methodThis review examined published articles up to March 2017. There were 13 cross-sectional observational studies that met the inclusion criteria, including relevance to cognitive reserve, subjects 60 years or older with normal cognition, mild cognitive impairment, and/or Alzheimer's disease, at least one quantitative measure of cognitive reserve, and fMRI as the imaging modality. Quality assessment of included studies was conducted using the Newcastle-Ottawa Scale adapted for cross-sectional studies.

resultsAcross the cognitive aging spectrum, medial temporal regions and an anterior or posterior cingulate cortex-seeded default mode network were associated with neural reserve. Frontal regions and the dorsal attentional network were related to neural compensation. Compared to neural reserve, neural compensation was more common in mild cognitive impairment and Alzheimer's disease.

conclusionsNeural reserve and compensation both support cognitive reserve, with compensation more common in later stages of the cognitive aging spectrum. Longitudinal and intervention studies are needed to investigate changes between neural reserve and compensation during the transition between clinical stages, and to explore the causal relationship between cognitive reserve and potential neural substrates.

Indexed as

Alzheimer DiseaseCognition DisordersCognitive AgingFunctional NeuroimagingHumansImage Processing, Computer-Assisted

Identifiers

PMID29244054
PMCPMC6246379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.