ArticleeLife2017
Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
- Localized Delivery of a Small Molecule Hedgehog Agonist via Poly(ε-caprolactone) Scaffolds Enhances Tendon-to-Bone Integration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Grafts in tendon repair.Materials today. Bio · 2026Review
- Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent manner.Nature communications · 2025Article
- PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration.Nature communications · 2025Article
- Stem and progenitor cells in the synovial joint as targets for regenerative therapy.Nature reviews. Rheumatology · 2025Review
- Single-Cell Analysis of Sex and Gender Differences in the Human Brain During Development and Disease.Cellular and molecular neurobiology · 2025Article
- Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing.NPJ Regenerative medicine · 2025Article
- A CD26Nature communications · 2025Article
- Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade.International journal of biological sciences · 2025Article
- A latent Axin2NPJ Regenerative medicine · 2024Article
- Single-cell analysis reveals distinct fibroblast plasticity during tenocyte regeneration in zebrafish.Science advances · 2023Article
- Targeting the hedgehog signaling pathway to improve tendon-to-bone integration.Osteoarthritis and cartilage · 2023Article
- Targeting osteocytes vs osteoblasts.Bone · 2023Review
- A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential.Cell stem cell · 2022Article
- Hypoxia inducible factor-1α mediates the mechanism of the Hedgehog pathway in tendinopathy repair by Asperosaponin VI.Regenerative therapy · 2022Review
- Hedgehog Signalling Contributes to Trauma-Induced Tendon Heterotopic Ossification and Regulates Osteogenesis through Antioxidant Pathway in Tendon-Derived Stem Cells.Antioxidants (Basel, Switzerland) · 2022Article
- RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification.Science advances · 2022Article
- The role of inhibitory circuits in hippocampal memory processing.Nature reviews. Neuroscience · 2022Review
- Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon.Bone & joint research · 2022Article
- Interneuronal dynamics facilitate the initiation of spike block in cortical microcircuits.Journal of computational neuroscience · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both extrinsic and intrinsic tissues contribute to tendon repair, but the origin and molecular functions of extrinsic tissues in tendon repair are not fully understood. Here we show that tendon sheath cells harbor stem/progenitor cell properties and contribute to tendon repair by activating Hedgehog signaling. We found that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.