Evidence map›Paper›PMID 29243589›Full record

ArticleeLife2017

Defective STIM-mediated store operated Ca

Ana Paula Arruda, Benedicte Mengel Pers, Günes Parlakgul, Ekin Güney, Ted Goh, Erika Cagampan, Grace Yankun Lee, Renata L Goncalves, Gökhan S Hotamisligil

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. CabioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026
    Review
  4. Review
  5. The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference.International journal of molecular sciences · 2023
    Review
  11. Store-operated CaPNAS nexus · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Role of CaInternational journal of molecular medicine · 2022
    Review
  16. Review
  17. Phenotyping ofBiomolecules · 2022
    Review
  18. Review
  19. Review
  20. Aberrant CaScience signaling · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ana Paula Arruda *Department of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.ORCID http://orcid.org/0000-0001-6179-2687
Benedicte Mengel Pers *Department of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Günes ParlakgulDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Ekin GüneyDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Ted GohDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Erika CagampanDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Grace Yankun LeeDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Renata L GoncalvesDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.
Gökhan S HotamisligilDepartment of Genetics and Complex Diseases, Sabri Ülker Center, Harvard TH Chan School of Public Health, Boston, United States.ORCID http://orcid.org/0000-0003-2906-1897
Broad Institute · USUniversity of Copenhagen · DK

Funding

TNF RECEPTOR FUNCTION IN INSULIN RESISTANCE AND OBESITYR01DK052539 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HOTAMISLIGIL, GOKHAN S · 1998 to 2017
$6.8M
The role of immunometabolic pathways in atherosclerosisR01HL125753 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HOTAMISLIGIL, GOKHAN S · 2015 to 2018
$1.6M
A Multi-user Super Resolution Microscope for Developmental BiologyS10RR029237 · NCRR · HARVARD UNIVERSITY · PI KUNES, SAMUEL M · 2010 to 2010
$1.0M
NCRR NIH HHS S10 RR029237NHLBI NIH HHS R01 HL125753NIDDK NIH HHS R01 DK052539NIH HHS DK52539
6 · The paper itself

Abstract

Defective Ca

Indexed as

AnimalsCalciumCations, DivalentCells, CulturedEndoplasmic ReticulumGene DeletionGene ExpressionGlycosylationHepatocytesMice, ObeseObesityStromal Interaction Molecule 1CalciumCations, DivalentStim1 protein, mouseStromal Interaction Molecule 1calciumcell biologyendoplasmic reticulumhuman biologyinsulin resistancemedicinemouseobesitySOCE

Identifiers

PMID29243589
PMCPMC5777820
OpenAlexW2771235975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.