ArticleJournal of biomedical optics2017
Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Rapid Quantitative Imaging of Heterogeneous Tissue Hemoglobin Dynamics Using Spatial Frequency Domain Imaging.Journal of vascular research · 2026Article
- Effects of volume management on free flap perfusion and metabolism in a large animal model study.Lab animal · 2024Article
- Numerical approach to quantify depth-dependent blood flow changes in real-time using the diffusion equation with continuous-wave and time-domain diffuse correlation spectroscopy.Biomedical optics express · 2023Article
- Reconstruction of optical coefficients in turbid media using time-resolved reflectance and calibration-free instrument response functions.Biomedical optics express · 2022Article
- New Approach to the Old Challenge of Free Flap Monitoring-Hyperspectral Imaging Outperforms Clinical Assessment by Earlier Detection of Perfusion Failure.Journal of personalized medicine · 2021Article
- Hyperspectral imaging and artificial intelligence to detect oral malignancy - part 1 - automated tissue classification of oral muscle, fat and mucosa using a light-weight 6-layer deep neural network.Head & face medicine · 2021Article
- Noninvasive Optical Assessment of Implanted Tissue-Engineered Construct SuccessTissue engineering. Part C, Methods · 2021Article
- Hyperspectral analysis for perioperative perfusion monitoring-a clinical feasibility study on free and pedicled flaps.Clinical oral investigations · 2021Article
- Small separation frequency-domain near-infrared spectroscopy for the recovery of tissue optical properties at millimeter depths.Biomedical optics express · 2019Article
- A Systematic Study of Vascular Distribution Characteristics and Axis Design of Various Flap Types.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Small separation diffuse correlation spectroscopy for measurement of cerebral blood flow in rodents.Biomedical optics express · 2018Article
- Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation.
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Registered trials
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