Evidence map›Paper›PMID 29243406›Full record

ArticleInfluenza and other respiratory viruses2018

The national burden of influenza-associated severe acute respiratory illness hospitalization in Zambia, 2011-2014.

Andros Theo, Stefano Tempia, Adam L Cohen, Paul Simusika, Edward Chentulo, Chikama Mukwangole Chikamukwa, Mwaka Monze

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Article in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

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27citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Andros TheoCavendish University School of Medicine, Lusaka, Zambia.ORCID 0000-0003-0838-2130
Stefano TempiaInfluenza Division, Centers for Disease Control and Prevention, Atlanta, USA.ORCID 0000-0003-4395-347X
Adam L CohenCavendish University School of Medicine, Lusaka, Zambia.
Paul SimusikaNational Influenza Center, Virology Laboratory, University Teaching Hospital, Lusaka, Zambia.
Edward ChentuloNational Influenza Center, Virology Laboratory, University Teaching Hospital, Lusaka, Zambia.
Chikama Mukwangole ChikamukwaLusaka Provincial Medical Office, Ministry of Health, Lusaka, Zambia.
Mwaka MonzeNational Influenza Center, Virology Laboratory, University Teaching Hospital, Lusaka, Zambia.

Funding

NCIRD CDC HHS U51 IP000828World Health Organization 001
6 · The paper itself

Abstract

backgroundEstimates of influenza-associated hospitalization are limited in low- and middle-income countries, especially in Africa.

objectiveTo estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Zambia.

methodsWe conducted active prospective hospital-based surveillance for SARI at the University Teaching Hospital (UTH) situated in Lusaka Province during 2011-2014. Upper respiratory tract samples were tested for influenza virus using a reverse transcriptase polymerase chain reaction assay. We estimated age-specific rates of influenza-associated SARI hospitalizations for the UTH using census and secondary data on respiratory hospitalizations following estimation approaches recommended by the World Health Organization. We used the UTH hospitalization rates as a proxy for Lusaka Province. These rates were adjusted for each of the remaining 9 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. Rates were expressed per 100,000 population.

resultsSARI cases accounted for 77.1% (13 389/17 354) of respiratory admissions at the UTH; 82.7% (11 859/14 344) and 50.8% (1530/3010) among individuals aged <5 and ≥5 years, respectively. Among SARI cases tested, the influenza virus detection rate was 5.5% (152/2734), 4.8% (48/998), and 6.0% (104/1736) among individuals aged <5 and ≥5 years, respectively. The mean annual national number of influenza-associated SARI hospitalizations was 6181 (95% CI: 4321-8041-rate: 43.9; 95% CI: 30.7-57.1); 4669 (95% CI: 3287-6051-rate: 187.7; 95% CI: 132.1-243.3) among children aged <5 years; and 1512 (95% CI: 1037-1987-rate: 13.1; 95% CI: 9.0-17.2) among individuals aged ≥5 years.

conclusionsThe burden of influenza-associated SARI hospitalizations was substantial and was highest among children aged <5 years.

Indexed as

HospitalizationAdolescentAdultAgedChildChild, PreschoolHumansInfantInfluenza, HumanInfluenza VaccinesMiddle AgedPandemicsRetrospective StudiesRisk FactorsSentinel SurveillanceYoung AdultInfluenza Vaccinesburdenhospitalizationinfluenzasevere acute respiratory illnessZambia

Identifiers

PMID29243406
PMCPMC5818337

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.