Evidence map›Paper›PMID 29243402›Full record

ArticleInfluenza and other respiratory viruses2018

National burden of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness in Kenya, 2012-2014.

Jeanette A Dawa, Sandra S Chaves, Bryan Nyawanda, Henry N Njuguna, Carolyne Makokha, Nancy A Otieno, Omu Anzala, Marc-Alain Widdowson, Gideon O Emukule

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeanette A DawaCollege of Health Sciences, Kenya AIDS Vaccine Institute (KAVI) - Institute of Clinical Research, University of Nairobi, Nairobi, Kenya.ORCID 0000-0001-9405-148X
Sandra S ChavesCenters for Disease Control and Prevention, Nairobi, Kenya.
Bryan NyawandaKenya Medical Research Institute (KEMRI), Kisumu, Kenya.
Henry N NjugunaCenters for Disease Control and Prevention, Nairobi, Kenya.
Carolyne MakokhaKenya Medical Research Institute (KEMRI), Kisumu, Kenya.
Nancy A OtienoKenya Medical Research Institute (KEMRI), Kisumu, Kenya.
Omu AnzalaCollege of Health Sciences, Kenya AIDS Vaccine Institute (KAVI) - Institute of Clinical Research, University of Nairobi, Nairobi, Kenya.
Marc-Alain WiddowsonCenters for Disease Control and Prevention, Nairobi, Kenya.
Gideon O EmukuleCenters for Disease Control and Prevention, Nairobi, Kenya.

Funding

Wellcome Trust 077092Wellcome Trust 084633Wellcome Trust 087547/Z/08/Z
6 · The paper itself

Abstract

backgroundInfluenza-associated respiratory illness was substantial during the emergence of the 2009 influenza pandemic. Estimates of influenza burden in the post-pandemic period are unavailable to guide Kenyan vaccine policy.

objectivesTo update estimates of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness (SARI) during a post-pandemic period (2012-2014) and describe the incidence of disease by narrow age categories.

methodsWe used data from Siaya County Referral Hospital to estimate age-specific base rates of SARI. We extrapolated these base rates to other regions within the country by adjusting for regional risk factors for acute respiratory illness (ARI), regional healthcare utilization for acute respiratory illness, and the proportion of influenza-positive SARI cases in each region, so as to obtain region-specific rates.

resultsThe mean annual rate of hospitalized influenza-associated SARI among all ages was 21 (95% CI 19-23) per 100 000 persons. Rates of non-hospitalized influenza-associated SARI were approximately 4 times higher at 82 (95% CI 74-90) per 100 000 persons. Mean annual rates of influenza-associated SARI were highest in children <2 years of age with annual hospitalization rates of 147 (95% CI of 134-160) per 100 000 persons and non-hospitalization rates of 469 (95% CI 426-517) per 100 000 persons. For the period 2012-2014, there were between 8153 and 9751 cases of hospitalized influenza-associated SARI and 31 785-38 546 cases of non-hospitalized influenza-associated SARI per year.

conclusionsThe highest burden of disease was observed among children <2 years of age. This highlights the need for strategies to prevent influenza infections in this age group.

Indexed as

HospitalizationAdolescentAdultAgedChildChild, PreschoolHumansInfantInfluenza, HumanInfluenza VaccinesKenyaMiddle AgedPandemicsRetrospective StudiesRisk FactorsSentinel SurveillanceInfluenza Vaccinesepidemiologyinfectionpneumoniavirus

Identifiers

PMID29243402
PMCPMC5818348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.