Evidence map›Paper›PMID 29243396›Full record

ArticleObesity (Silver Spring, Md.)2018

Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction.

Deana Mikhalkova, Sujata R Holman, Hui Jiang, Mohammed Saghir, Eric Novak, Andrew R Coggan, Robert O'Connor, Adil Bashir, Ali Jamal, Daniel S Ory and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 116 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Deana MikhalkovaCardiovascular Division, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Sujata R HolmanCardiovascular Division, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Hui JiangDiabetic Cardiovascular Disease Center, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Mohammed SaghirCardiovascular Division, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Eric NovakCardiovascular Division, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Andrew R CogganMallinckrodt Institute of Radiology, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.ORCID 0000-0002-7723-8872
Robert O'ConnorMallinckrodt Institute of Radiology, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Adil BashirMallinckrodt Institute of Radiology, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Ali JamalMallinckrodt Institute of Radiology, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Daniel S OryDiabetic Cardiovascular Disease Center, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
Jean E SchafferDiabetic Cardiovascular Disease Center, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.
J Christopher EagonDepartment of Surgery, School of Medicine, Washington University, St Louis, Missouri, USA.
Linda R PetersonCardiovascular Division, Department of Medicine, School of Medicine, Washington University, St Louis, Missouri, USA.ORCID 0000-0001-8766-4552
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2013 to 2026
$27.1M
Lipid Biomarkers for Diabetic Heart DiseaseP20HL113444 · NHLBI · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 2012 to 2016
$4.7M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHLBI NIH HHS P20 HL113444NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

objectiveTo determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).

methodsA primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22).

resultsAfter surgery-induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P < 0.02, P < 0.001, and P = 0.007, respectively); echo-derived e' increased (P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate.

conclusionsSurgery-induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity-related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.

Indexed as

Bariatric SurgeryFemaleHeartHeart FailureHumansMaleMiddle AgedObesityStroke Volume

Identifiers

PMID29243396
PMCPMC5783730
OpenAlexW2772076325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.