Evidence map›Paper›PMID 29243206›Full record

ArticleJournal of physiology and biochemistry2018

I

Jian-Wen Hou, Wei Li, Yu-Dong Fei, Yi-He Chen, Qian Wang, Yue-Peng Wang, Yi-Gang Li

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jian-Wen HouDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.
Wei LiDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.
Yu-Dong FeiDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.
Yi-He ChenDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.
Qian WangDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China.
Yue-Peng WangDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. ypwang555@aliyun.com.
Yi-Gang LiDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. liyigang@xinhuamed.com.cn.
XinHua Hospital · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 81270258National Natural Science Foundation of China 81370257National Natural Science Foundation of China 81530015National Natural Science Foundation of China 81670414Shanghai City Committee of Science and Technology Research Nos. 12411951900, 13140903801, and 14441902502
6 · The paper itself

Abstract

Rate-dependent repolarization (RDR) of action potential (AP) in cardiomyocyte plays a critical role in the genesis of arrhythmias and RDR in atrium has been linked with atrial fibrillation. However, detailed studies focusing on the role of RDR in rabbit atrium are scant. In this study, atrial cells were isolated from rabbit heart and rate-dependent property was explored in single atrial cell to elucidate the underlying mechanism. Our results indicated that rate-dependent prolongation was evident at the action potential duration at 20% (APD20) and 50% (APD50) repolarization but not at 90% repolarization (APD90) under control condition. Using transient outward potassium current (I

Indexed as

4-AminopyridineAction PotentialsAnimalsAnti-Arrhythmia AgentsCalcium Channel BlockersCalcium Channels, L-TypeCells, CulturedElectrophysiological PhenomenaHeart AtriaKineticsMyocytes, CardiacNifedipinePotassium Channel BlockersPyridinesRabbitsSingle-Cell Analysis4-Aminopyridine6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)(1,2,4)triazolo(4,3-a)pyridineAnti-Arrhythmia AgentsCalcium Channel BlockersCalcium Channels, L-TypeNifedipinePotassium Channel BlockersPyridinesSodium Channel BlockersSodium ChannelsTriazolesAtrial myocytesLate sodium currentL-type calcium currentRate-dependent repolarizationTransient outward potassium current

Identifiers

PMID29243206
OpenAlexW2772664156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.