ArticleJournal of assisted reproduction and genetics2018
Comparison of the development of human embryos cultured in either an EmbryoScope or benchtop incubator.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Pregnancy and neonatal outcomes following time-lapse versus conventional embryo culture: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Morphometric Blastocyst Assessment: A Retrospective Study Examining the Relationship Between Blastocyst Diameter and Area and Pregnancy Outcomes in Assisted Reproduction Technology Cycles.Journal of clinical medicine · 2025Article
- Culture conditions in the IVF laboratory: state of the ART and possible new directions.Journal of assisted reproduction and genetics · 2023Review
- The GGC Medium Reduces the DNA Fragmentation of Human Spermatozoa viaArchives of Razi Institute · 2023Article
- Comparison of DNA methylation profiles of human embryos cultured in either uninterrupted or interrupted incubators.Journal of assisted reproduction and genetics · 2023Article
- Body mass index, not race, may be associated with an alteration in early embryo morphokinetics during in vitro fertilization.Journal of assisted reproduction and genetics · 2021Article
- Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer.Journal of assisted reproduction and genetics · 2021Article
- Comparison of pregnancy outcomes using a time-lapse monitoring system for embryo incubation versus a conventional incubator in in vitro fertilization: An age-stratification analysis.Clinical and experimental reproductive medicine · 2021Article
- HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.Reproduction (Cambridge, England) · 2021Article
- Clinical pregnancy is significantly associated with the blastocyst width and area: a time-lapse study.Journal of assisted reproduction and genetics · 2021Article
- Analysis of Morphokinetic Parameters of Feline Embryos Using a Time-Lapse System.Animals : an open access journal from MDPI · 2021Article
- Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF/ICSI treatment cycles: a cohort study.Human reproduction open · 2021Article
- Can Time-Lapse Incubation and Monitoring Be Beneficial to Assisted Reproduction Technology Outcomes? A Randomized Controlled Trial Using Day 3 Double Embryo Transfer.Frontiers in physiology · 2021Article
- Predicting pregnancy test results after embryo transfer by image feature extraction and analysis using machine learning.Scientific reports · 2020Article
- Spontaneous blastocyst collapse as an embryo marker of low pregnancy outcome: A Time-Lapse study.JBRA assisted reproduction · 2020Article
- Comparing transcriptome profiles of human embryo cultured in closed and standard incubators.PeerJ · 2020Article
- Good practice recommendations for the use of time-lapse technologyHuman reproduction open · 2020Article
- Time-Lapse Culture Improves Development and Pregnancy Outcomes of Sibling Normally Fertilized Oocytes: A Prospective Multicenter Study.Reproductive medicine and biologyArticle
- A Study to Find Optimal Intra-cytoplasmic Sperm Injection Timing of Oocytes Matured from Germinal Vesicle inJournal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this current study, our main goal was to establish that EmbryoScope incubation environment is comparable to standard incubation.
methodsThe development of sibling human zygotes was compared after culture in either a benchtop incubator (SI) or an EmbryoScope time-lapse incubator (ES). Between May 2015 to April 2016, a total of 581 normally fertilized 2PN, pronuclear-stage embryos, from 47 patients were allocated to culture in either a benchtop incubator (SI) or an EmbryoScope incubator (ES).
resultsThe development of embryos to cleavage (up to day 3) and blastocyst stages (day 5/6) was compared between the two different incubators. The proportion of good quality embryos was higher in the ES group compared to the SI on day 2 (66.8 vs. 50.5%, P = 0.014) and on day 3 (75.1 vs. 56.0%, P = 0.006). Those differences were statistically significant. A higher proportion of embryos developed to good quality blastocysts when cultured in the EmbryoScope compared to the benchtop (49.4 vs. 42.0%, P = 0.24), but this was not significant. Finally, no significant differences were noted with the proportion of blastocysts chosen for cryopreservation on day 5/6 in the two incubators.
conclusionsThe findings support the view that the EmbryoScope incubator supports at least equivalent in vitro development of human embryos compared to other standard incubation methods and may promote improved development during early cleavage stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.