Evidence map›Paper›PMID 29243124›Full record

ReviewVirchows Archiv : an international journal of pathology2018

Gut microbiome: a new player in gastrointestinal disease.

Gregor Gorkiewicz, Alexander Moschen

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05720793 (A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05720793 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder

TypeinterventionalSponsorValerie TaylorRan2023 to 2024Enrolled20ConditionsObsessive-Compulsive DisorderArmsFMT Capsule + SIMBA Capsule
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Meta-analysis ofFrontiers in cellular and infection microbiology · 2025
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Exploring the Link Between Atopic Dermatitis and Eosinophilic Esophagitis.The Journal of clinical and aesthetic dermatology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Evolution and Competitive Struggles ofInternational journal of molecular sciences · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Journal of biosciences · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gregor GorkiewiczInstitute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010, Graz, Austria. gregor.gorkiewicz@medunigraz.at.ORCID http://orcid.org/0000-0003-1149-4782
Alexander MoschenChristian Doppler Laboratory for Mucosal Immunology & Division of Internal Medicine I, Department of Medicine, Medical University Innsbruck, Peter-Mayr-Strasse 1, 6020, Innsbruck, Austria.
Christian Doppler Klinik · ATMedical University of Graz · AT

Funding

FWF FWF W1241-B18
6 · The paper itself

Abstract

The gastrointestinal (GI) tract harbors a diverse and host-specific gut microbial community. Whereas host-microbe interactions are based on homeostasis and mutualism, the microbiome also contributes to disease development. In this review, we summarize recent findings connecting the GI microbiome with GI disease. Starting with a description of biochemical factors shaping microbial compositions in each gut segment along the longitudinal axis, improved histological techniques enabling high resolution visualization of the spatial microbiome structure are highlighted. Subsequently, inflammatory and neoplastic diseases of the esophagus, stomach, and small and large intestines are discussed and the respective changes in microbiome compositions summarized. Finally, approaches aiming to restore disturbed microbiome compositions thereby promoting health are discussed.

Indexed as

Gastrointestinal MicrobiomeGastrointestinal DiseasesHumansCarcinogenesisDysbiosisFecal microbiome transplantationGut microbiomeInflammationSpatial microbiome organization

Identifiers

PMID29243124
PMCPMC5849673
OpenAlexW2771465307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.