Evidence map›Paper›PMID 29243072›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

Volume-based glucose metabolic analysis of FDG PET/CT: The optimum threshold and conditions to suppress physiological myocardial uptake.

Osamu Manabe, Markus Kroenke, Tadao Aikawa, Atsuto Murayama, Masanao Naya, Atsuro Masuda, Noriko Oyama-Manabe, Kenji Hirata, Shiro Watanabe, Tohru Shiga and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Clinical significance of visual cardiacCancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  6. Impact of respiratory gating and ECG gating onJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  7. Clinical features and prognosis of isolated cardiac sarcoidosis diagnosed using new guidelines with dedicated FDG PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  8. Review
  9. Article
  10. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  11. Article
  12. Myocardial perfusion imaging in cardiac sarcoidosis: A "sine qua non" for prognosis assessment?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  13. Non-alcoholic fatty liver disease with reduced myocardial FDG uptake is associated with coronary atherosclerosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  14. Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  15. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Observational
  16. Review
  17. Value of simultaneous assessment of cardiac functions by PET/MRI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  18. Recommendations forJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Review
  19. Use ofEuropean journal of nuclear medicine and molecular imaging · 2019
    Article
  20. Does simplified quantitative analysis ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Osamu ManabeDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan. osamumanabe817@med.hokudai.ac.jp.
Markus KroenkeDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.
Tadao AikawaDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Atsuto MurayamaDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.
Masanao NayaDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Atsuro MasudaDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
Noriko Oyama-ManabeDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Kenji HirataDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.
Shiro WatanabeDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.
Tohru ShigaDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.
Chietsugu KatohFaculty of Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Nagara TamakiDepartment of Nuclear Medicine, Hokkaido University Graduate School of Medicine, N15 W7, Kita-Ku, Sapporo, Hokkaido, 0608638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFDG PET/CT plays a significant role in the diagnosis of inflammatory heart diseases and cardiac tumors. We attempted to determine the optimal FDG uptake threshold for volume-based analyses and to evaluate the relationship between the myocardial physiological uptake volume in FDG PET and several clinical factors.

methodsA total of 190 patients were retrospectively analyzed. The cardiac metabolic volume (CMV) was defined as a volume within the boundary determined by a threshold (SUVmean of blood pool × 1.5).

resultsThe SUVmean of the blood pool measured in the descending aorta (DA) (r = 0.86, intraclass correlation coefficient [ICC] = 0.93, P < 0.0001) and that in the left ventricle (LV) cavity (r = 0.87, ICC = 0.90, P < 0.0001) showed high inter-operator reproducibility. However, the SUVmean in the LV cavity showed a significant correlation with the CMV (P = 0.0002, r = 0.26). The CMV in the patients who fasted < 18 hours were significantly higher (49.7  ±  73.2 vs. 18.0  ±  53.8 mL, P = 0.0013) compared to the patients with > 18-hour fasting. The multivariate analysis demonstrated that only the fasting period > 18 hours was independently associated with CMV = 0.

conclusionOur findings revealed that the DA is suitable to decide the threshold for the volume-based analysis. The fasting time was significantly associated with the cardiac FDG uptake.

Indexed as

Positron Emission Tomography Computed TomographyAgedAorta, ThoracicBlood VolumeFemaleFluorodeoxyglucose F18GlucoseHeart DiseasesHumansMaleMiddle AgedMyocardiumRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesFluorodeoxyglucose F18GlucoseRadiopharmaceuticals18F-FluorodeoxyglucosefastingMetabolism: PETPETphysiological uptake

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.