Evidence map›Paper›PMID 29243064›Full record

ArticleVirus genes2018

Interferon lambda4 polymorphism is not associated with human papillomavirus infection outcome.

Fabiana Cannella, Carolina Scagnolari, Maura Statzu, Ilaria Sciandra, Nadia Recine, Gabriella d'Ettorre, Guido Antonelli, Alessandra Pierangeli

Abstract read
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In one paragraph

Article in Virus genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fabiana CannellaLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy.
Carolina ScagnolariLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy. carolina.scagnolari@uniroma1.it.
Maura StatzuLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy.
Ilaria SciandraLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy.
Nadia RecineDepartment of Obstetric and Gynaecological Sciences and Urologic Sciences, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Azienda Policlinico Umberto I, Rome, Italy.
Guido AntonelliLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy.
Alessandra PierangeliLaboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University, Viale di Porta Tiburtina 28, 00185, Rome, Italy.

Funding

Sapienza Università di Roma C26A199B4N
6 · The paper itself

Abstract

Interferon (IFN) lambdas are important specific components of the mucosal innate immune response. The IFN lambda 4 (IFNL4) dinucleotide polymorphism (ΔG/TT) determines the IFN lambdas and related Interferon-stimulated genes activation, in HCV and other chronic infections. Our group first reported that IFN Lambda response was impaired in high-risk Human Papillomavirus (HPV) cervical infections and in precancerous lesions. Accordingly, we sought to evaluate the possible role of the IFNL4 polymorphism in determining HPV infection outcome. The ΔG/TT alleles were not differently distributed in 221 women with high- or low-risk HPV infection, with HPV infection clearance or persistence, and with abnormal cytology.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticHumansInterferon LambdaInterleukinsPapillomaviridaePapillomavirus InfectionsTreatment OutcomeIFNL4 protein, humanInterferon LambdaInterleukinsHPVIFN lambda 4Persistent infectionSingle-nucleotide polymorphismsType III IFN

Identifiers

PMID29243064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.