ArticleAnnals of nuclear medicine2018
Evaluation of bone metastatic burden by bone SPECT/CT in metastatic prostate cancer patients: defining threshold value for total bone uptake and assessment in radium-223 treated patients.
Article in Annals of nuclear medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- EANM practice guideline for quantitative SPECT-CT.European journal of nuclear medicine and molecular imaging · 2023Guideline
- Quantitative bone SPECT/CT-derived tumor burden as a prognostic biomarker in metastatic castration-resistant prostate cancer treated with Ra-223.EJNMMI reports · 2026Article
- Article
- Development of a novel phantom for evaluating jawbone SPECT targeting medication-related osteonecrosis of the jaw.Oral radiology · 2025Article
- Diagnostic Ability of Quantitative Parameters of Whole-Body Bone SPECT/CT Using a Full-Ring 360° Cadmium-Zinc-Telluride Camera for Detecting Bone Metastasis in Patients with Prostate Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Predictability of combining Technetium-99m-galactosyl human serum albumin single-photon emission computed tomography/computed tomography and indocyanine green clearance test for posthepatectomy liver failure.Japanese journal of radiology · 2024Article
- Evaluation of two-dimensional total bone uptake (2D-TBU) and bone scan index (BSI) extracted from active bone metastatic burden on the bone scintigraphy in patients with radium-223 treatment.Annals of nuclear medicine · 2024Article
- Correlation analysis between the quantitative parameters of iodine-131 single-photon emission computed tomography-computed tomography thyroid bed uptake and the efficacy of radioactive iodine adjuvant therapy for papillary thyroid cancer.Quantitative imaging in medicine and surgery · 2024Article
- Nuclear medicine practice in Japan: a report of the ninth nationwide survey in 2022.Annals of nuclear medicine · 2024Article
- Wnt1 induces osteoblastic changes in a well-established osteolytic skeletal metastatic model derived from breast cancer.Cancer reports (Hoboken, N.J.) · 2023Article
- Quantitative [EJNMMI physics · 2022Article
- Volumetric analysis of mandibular lesions with SPECT/CT: a pilot clinical study of maximum standardized uptake value.Polish journal of radiology · 2022Article
- Satisfied quantitative value can be acquired by short-time bone SPECT/CT using a whole-body cadmium-zinc-telluride gamma camera.Scientific reports · 2021Article
- Analysis of medication-related osteonecrosis of the jaw with bone SPECT/CT: relationship between patient characteristics and maximum standardized uptake value.Dento maxillo facial radiology · 2021Article
- Estimation of the lower limits for feasible Ra-223 SPECT imaging: a Monte Carlo simulation study.Asia Oceania journal of nuclear medicine & biology · 2021Article
- Assessment of inflammatory jaw pathologies using bone SPECT/CT maximum standardized uptake value.Dento maxillo facial radiology · 2020Article
- Examination of cross-calibration and concentration linearity with quantitative gallium-67 single-photon emission computed tomography: phantom experiment.Radiological physics and technology · 2020Article
- Dynamic changes of bone metastasis predict bone-predominant status to benefit from radium-223 dichloride for patients with castration-resistant prostate cancer.Cancer medicine · 2020Article
- A novel tool for improving the interpretation of isotope bone scans in metastatic prostate cancer.The British journal of radiology · 2020Article
- Quantitative evaluation of anti-resorptive agent-related osteonecrosis of the jaw using bone single photon emission computed tomography in clinical settings: relationship between clinical stage and imaging.Annals of nuclear medicine · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo establish a new three-dimensional quantitative evaluation method for bone metastasis, we applied bone single photon emission tomography with computed tomography (SPECT/CT). The total bone uptake (TBU), which measures active bone metastatic burden, was calculated as the sum of [mean uptake obtained as standardized uptake value (SUV) above a cut-off level] × (the volume of the lesion) in the trunk using bone SPECT/CT. We studied the threshold value and utility of TBU in prostate cancer patients treated with radium-223 (Ra-223) therapy.
methodsTo establish the threshold value of TBU, we compared bone metastatic and non-metastatic regions in 61 prostate cancer patients with bone metastasis and 69 without. Five fixed sites in each patient were selected as evaluation points and divided into bone metastatic and non-metastatic sites. Sensitivity and specificity analysis was applied to establish the threshold level. Using the obtained threshold value, we then calculated the TBU in nine prostate cancer patients who received Ra-223 therapy, and compared the results with the bone scan index (BSI) by BONENAVI
resultsUptake was significantly lower in non-metastatic sites in patients with bone metastasis than in patients without metastasis. Sensitivity and specificity analysis revealed SUV = 7.0 as the threshold level. There was a discrepancy between TBU and BSI change in two of the nine patients, in whom TBU change correlated with visual judgement, but BSI change did not. In two patients, BSI was nearly 0 throughout the course, but the TBU was positive and changed, although the change was not large. These results suggest that TBU may be more accurate and sensitive than BSI for quantitative evaluation of active bone metastatic burden.
conclusionWe established a threshold value (SUV > 7.0) for three-dimensional TBU for evaluating active bone metastatic burden in prostate cancer patients using bone SPECT/CT. Despite the small number of patients, we expect the change in TBU could be more accurate and sensitive than the change in BSI among patients who received Ra-223.
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