Evidence map›Paper›PMID 29242985›Full record

ArticleDiabetologia2018

Increasing risk of psychiatric morbidity after childhood onset type 1 diabetes: a population-based cohort study.

Daniel Dybdal, Janne S Tolstrup, Stine M Sildorf, Kirsten A Boisen, Jannet Svensson, Anne Mette Skovgaard, Grete K Teilmann

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Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Daniel DybdalDepartment of Paediatrics and Adolescent Medicine, Nordsjællands Hospital, Dyrehavevej 29, DK 3400, Hillerød, Denmark.
Janne S TolstrupNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Stine M SildorfDepartment of Paediatrics and Adolescent Medicine, Herlev Hospital, Herlev, Denmark.
Kirsten A BoisenCentre of Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.
Jannet SvenssonDepartment of Paediatrics and Adolescent Medicine, Herlev Hospital, Herlev, Denmark.
Anne Mette SkovgaardNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Grete K TeilmannDepartment of Paediatrics and Adolescent Medicine, Nordsjællands Hospital, Dyrehavevej 29, DK 3400, Hillerød, Denmark. grete.katrine.teilmann@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThe aim of this study was to investigate psychiatric morbidity following childhood onset of type 1 diabetes.

methodsIn a matched, population-based cohort study based on Danish national registers, we identified children and adolescents who had been diagnosed as an in- or outpatient with type 1 diabetes before the age of 18, and afterwards diagnosed with a psychiatric disorder (n = 5084). Control individuals were matched according to sex and date of birth (n = 35,588). The Cox proportional hazards model was used to assess associations between type 1 diabetes and the incidence of psychiatric disorders as well as the effects of age at onset and duration of type 1 diabetes on the risk of subsequently developing psychiatric morbidities.

resultsAn increased risk of being diagnosed with mood disorders and anxiety, dissociative, eating, stress-related and somatoform disorders was observed in both sexes in the years following type 1 diabetes onset, with the highest risk observed five years or more after onset (HR 1.55 [95% CI 1.38, 1.74]). The risk of psychoactive substance-misuse disorders increased significantly only in boys, and the risk of personality disorders increased only in girls. CONCLUSIONS/

interpretationIn the years following type 1 diabetes onset, an increased risk of eating disorders, anxiety and mood disorders, substance misuse, and personality disorders was found. These findings highlight a clinical need to monitor the mental health of children and adolescents in the years following type 1 diabetes onset to identify and treat psychiatric problems associated with type 1 diabetes.

Indexed as

AdolescentAnxiety DisordersCase-Control StudiesChildChild, PreschoolCohort StudiesDenmarkDiabetes Mellitus, Type 1Feeding and Eating DisordersFemaleFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMaleAdolescentsAnxietyChildrenComorbidityEating disorderMood disorderPersonality disorderPsychiatric illnessSubstance misuseType 1 diabetes mellitus

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.