Evidence map›Paper›PMID 29242753›Full record

ArticleLiver research (Beijing, China)2017

Activating transcription factor 3 in immune response and metabolic regulation.

Kavita Jadhav, Yanqiao Zhang

Open access · goldAbstract read
In one paragraph

Article in Liver research (Beijing, China), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
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  12. Exponential Combination ofACS chemical biology · 2024
    Article
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  15. Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. The multifaceted roles of activating transcription factor 3 (ATF3) in inflammatory responses - Potential target to regulate neuroinflammation in acute brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  17. Article
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  20. ATF3 in atherosclerosis: a controversial transcription factor.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kavita JadhavDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Yanqiao ZhangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Northeast Ohio Medical University · US

Funding

Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK102619 · NIDDK · UNIVERSITY OF ARIZONA · PI Yanqiao Zhang · 2015 to 2026
$4.0M
Regulation of Lipid and Lipoprotein Metabolism by Nuclear ReceptorsR01HL103227 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI YIN, LIYA, ZHANG, YANQIAO · 2011 to 2019
$3.1M
Identification of Novel Genes/Pathways That Regulate Lipid and Glucose MetabolismR01DK095895 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2012 to 2015
$1.3M
Carboxylesterase 1 in Alcoholic Liver DiseaseR21AA024946 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2016 to 2017
$398k
NHLBI NIH HHS R01 HL103227NIAAA NIH HHS R21 AA024946NIDDK NIH HHS R01 DK095895NIDDK NIH HHS R01 DK102619
6 · The paper itself

Abstract

Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element binding protein (CREB) family of transcription factors. In response to stress stimuli, ATF3 forms dimers to activate or repress gene expression. Further, ATF3 modulates the immune response, atherogenesis, cell cycle, apoptosis, and glucose homeostasis. Recent studies have shown that ATF3 may also be involved in pathogenesis of other diseases. However, more studies are needed to determine the role of ATF3 in metabolic regulation.

Indexed as

Activating transcription factor 3 (ATF3)Glucose homeostasisImmuneLiver injuryOncogenesis

Identifiers

PMID29242753
PMCPMC5724780
OpenAlexW2746703687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.