Evidence map›Paper›PMID 29242602›Full record

ArticleScientific reports2017

Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C).

Motahareh Moghtadaei, Ellen Langille, Sara A Rafferty, Oleg Bogachev, Robert A Rose

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cardiomyocyte Deletion ofFrontiers in physiology · 2021
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Motahareh MoghtadaeiDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
Ellen LangilleDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
Sara A RaffertyDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
Oleg BogachevDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
Robert A RoseDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada. robert.rose@ucalgary.ca.

Funding

CIHR 142486CIHR MOP 93718
6 · The paper itself

Abstract

Natriuretic peptides (NPs) play essential roles in the regulation of cardiovascular function. NP effects are mediated by receptors known as NPR-A, NPR-B or NPR-C. NPs have potent effects on regulation of heart rate (HR) by the autonomic nervous system (ANS), but the role of NPR-C in these effects has not been investigated. Accordingly, we have used telemetric ECG recordings in awake, freely moving wildtype and NPR-C knockout (NPR-C

Indexed as

Heart RateAnimalsArrhythmias, CardiacAutonomic Nervous SystemGene Knockout TechniquesMiceReceptors, Atrial Natriuretic Factoratrial natriuretic factor receptor CReceptors, Atrial Natriuretic Factor

Identifiers

PMID29242602
PMCPMC5730580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.