Evidence map›Paper›PMID 29242407›Full record

ArticleAging2017

Central role of the p53 pathway in the noncoding-RNA response to oxidative stress.

Paola Fuschi, Matteo Carrara, Christine Voellenkle, Jose Manuel Garcia-Manteiga, Paolo Righini, Biagina Maimone, Elena Sangalli, Francesco Villa, Claudia Specchia, Mario Picozza and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. MiRNA Dysregulation in Brain Injury: AnCurrent neuropharmacology · 2025
    Article
  6. Fundamentals of redox regulation in biology.Nature reviews. Molecular cell biology · 2024
    Review
  7. Genes · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Emerging Role of MiR-192-5p in Human Diseases.Frontiers in pharmacology · 2021
    Review
  18. Review
  19. Article
  20. Alcohol Promotes Exosome Biogenesis and ReleaseFrontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Paola FuschiMolecular Cardiology Laboratory, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Matteo CarraraMolecular Cardiology Laboratory, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Christine VoellenkleMolecular Cardiology Laboratory, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Jose Manuel Garcia-ManteigaCenter for Translational Genomics and BioInformatics, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Paolo RighiniOperative Unit of Vascular Surgery I, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Biagina MaimoneMolecular Cardiology Laboratory, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Elena SangalliCardiovascular Research Unit, IRCCS MultiMedica, 20138, Milan, Italy.
Francesco VillaCardiovascular Research Unit, IRCCS MultiMedica, 20138, Milan, Italy.
Claudia SpecchiaCardiovascular Research Unit, IRCCS MultiMedica, 20138, Milan, Italy.
Mario PicozzaVascular Pathology Laboratory, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, 00167, Rome, Italy.
Giovanni NanoOperative Unit of Vascular Surgery I, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
Carlo GaetanoDivision of Cardiovascular Epigenetics, Department of Cardiology, Goethe University, Frankfurt am Main, 60596, Germany.
Gaia SpinettiCardiovascular Research Unit, IRCCS MultiMedica, 20138, Milan, Italy.
Annibale A PucaCardiovascular Research Unit, IRCCS MultiMedica, 20138, Milan, Italy.
Alessandra MagentaVascular Pathology Laboratory, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, 00167, Rome, Italy.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico S. Donato, 20097, San Donato Milanese, Milan, Italy.
IRCCS Policlinico San Donato · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Dermopatico dell'Immacolata · ITGoethe University Frankfurt · DEMultiMedica · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress plays a fundamental role in many conditions. Specifically, redox imbalance inhibits endothelial cell (EC) growth, inducing cell death and senescence. We used global transcriptome profiling to investigate the involvement of noncoding-RNAs in these phenotypes. By RNA-sequencing, transcriptome changes were analyzed in human ECs exposed to H

Indexed as

AgedAged, 80 and overCell LineFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideMaleOxidantsOxidation-ReductionOxidative StressRNA, UntranslatedTranscriptomeTumor Suppressor Protein p53Hydrogen PeroxideOxidantsRNA, UntranslatedTP53 protein, humanTumor Suppressor Protein p53endotheliumlong noncoding RNAsmicroRNAsoxidative stressp53

Identifiers

PMID29242407
PMCPMC5764393
OpenAlexW2774383018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.