Evidence map›Paper›PMID 29242300›Full record

ArticleHaematologica2018

Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.

Fabian Knörr, Christine Damm-Welk, Stephanie Ruf, Vijay Kumar Singh, Martin Zimmermann, Alfred Reiter, Wilhelm Woessmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fabian KnörrNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen.
Christine Damm-WelkNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen Christine.Damm-Welk@paediat.med.uni-giessen.de.
Stephanie RufNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen.
Vijay Kumar SinghNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen.
Martin ZimmermannDepartment of Pediatric Hematology and Oncology, Children's Hospital, Hannover Medical School, Germany.
Alfred ReiterNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen.
Wilhelm WoessmannNHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen.
University of Giessen · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-γ, interferon γ-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response.

Indexed as

AdolescentAnaplastic Lymphoma KinaseChildChild, PreschoolCytokinesFemaleHumansImmunityInfantLymphoma, Large-Cell, AnaplasticMalePrognosisTumor BurdenAnaplastic Lymphoma KinaseCytokines

Identifiers

PMID29242300
PMCPMC5830391
OpenAlexW2772612669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.