Evidence map›Paper›PMID 29242297›Full record

ArticleHaematologica2018

Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.

François Lemonnier, Elsa Poullot, Aurélie Dupuy, Lucile Couronné, Nadine Martin, Laurianne Scourzic, Virginie Fataccioli, Julie Bruneau, Rob A Cairns, Tak W Mak and 3 more

Registry-linked trialOpen access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07060001 (Evaluation of the Efficacy of Hypomethylating Agent Versus Standard Intensive Chemotherapy Induction Based on 5hmC - a Novel, Blood Epigenetic Marker for Assessing Measurable Residual Disease in Patients With Acute Myeloid Leukemia), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07060001 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Efficacy of Hypomethylating Agent Versus Standard Intensive Chemotherapy Induction Based on 5hmC - a Novel, Blood Epigenetic Marker for Assessing Measurable Residual Disease in Patients With Acute Myeloid Leukemia

TypeinterventionalSponsorThe Methodist Hospital Research InstituteRan2026 to 2029Enrolled112ConditionsAcute Myeloid Leukemia (AML), Acute Myeloid Leukaemia (AML)Arms5hmC Biomarker, Venetoclax, Decitabine 20 mg/m²/day for 5 days, Azacitidine (AZA), Cytarabine (Ara-C)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

François LemonnierINSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France.
Elsa PoullotUniversité Paris-Est, Faculté de Médecine, Créteil, France.
Aurélie DupuyINSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France.
Lucile CouronnéINSERMU1170, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.
Nadine MartinINSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France.
Laurianne ScourzicINSERMU1170, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.
Virginie FataccioliINSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France.
Julie BruneauDépartement de Pathologie, Hôpital Necker Enfants Malades, APHP, Paris, France.
Rob A CairnsCampbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Canada.
Tak W MakCampbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Canada.
Olivier A BernardINSERMU1170, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France.
Laurence de LevalInstitute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
Philippe GaulardINSERMU955 équipe 9, Institut Mondor de Recherche Biomédicale, Créteil, France philippe.gaulard@aphp.fr.
Inserm · FRInstitut Gustave Roussy · FRAssistance Publique – Hôpitaux de Paris · FRPrincess Margaret Cancer Centre · CAHôpital Necker-Enfants Malades · FRInstitut Mondor de Recherche Biomédicale · FRUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

5-MethylcytosineEpigenesis, GeneticHumansLymphoma, T-Cell, PeripheralMethylation5-hydroxymethylcytosine5-Methylcytosine

Identifiers

PMID29242297
PMCPMC5830377
OpenAlexW2772537975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.