Evidence map›Paper›PMID 29242273›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss.

Michael R Strug, Ren-Wei Su, Tae Hoon Kim, Alessandro Mauriello, Carlo Ticconi, Bruce A Lessey, Steven L Young, Jeong Mook Lim, Jae-Wook Jeong, Asgerally T Fazleabas

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mechanisms of Regeneration and Fibrosis in the Endometrium.Annual review of cell and developmental biology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Notch signaling in reproduction.Trends in endocrinology and metabolism: TEM · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk.International journal of molecular sciences · 2019
    Review
  17. Article
  18. Inside the Endometrial Cell Signaling Subway: Mind the Gap(s).International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Michael R StrugDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA.
Ren-Wei SuDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA.
Tae Hoon KimDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA.
Alessandro MaurielloSection of Gynecology and Obstetrics, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Carlo TicconiSection of Gynecology and Obstetrics, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Bruce A LesseyDepartment of Obstetrics and Gynecology, Greenville Health System, Greenville, South Carolina, USA.
Steven L YoungDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jeong Mook LimWorld Class University (WCU) Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Jae-Wook JeongDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA.
Asgerally T FazleabasDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA.
Michigan Reproductive Medicine · USMichigan State University · USUniversity of Rome Tor Vergata · ITPrisma Health · USSeoul National University · KRUniversity of North Carolina at Chapel Hill · US

Funding

Modulation of the Receptive Endometrium by CGR01HD042280 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FAZLEABAS, ASGERALLY T. · 2003 to 2020
$4.6M
Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
The Role of Recombination Signal Binding Protein-J-kappa in PregnancyF30HD082951 · NICHD · MICHIGAN STATE UNIVERSITY · PI STRUG, MICHAEL · 2015 to 2015
$44k
NICHD NIH HHS F30 HD082951NICHD NIH HHS R01 HD042280
6 · The paper itself

Abstract

Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-γ. Notch signaling through its transcription factor recombination signal binding protein Jκ (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse uterus ( Pgr

Indexed as

RegenerationAbortion, HabitualAdultAnimalsEndometriumFemaleHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinInterferon-gammaMacrophagesMiceMice, KnockoutMyometriumPostpartum PeriodPregnancyIFNG protein, humanIFNG protein, mouseImmunoglobulin J Recombination Signal Sequence-Binding ProteinInterferon-gammaRBPJ protein, humanRbpj protein, mousedecidualizationembryo implantationIFN-γNotch

Identifiers

PMID29242273
PMCPMC6207278
OpenAlexW2774788267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.