ArticleArteriosclerosis, thrombosis, and vascular biology2018
SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Smooth muscle cell (SMC)-Specific SNRK deletion in mouse causes congenital short bowel syndrome and premature death.Biochemistry and biophysics reports · 2025Article
- SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Exosomes derived from minor salivary gland mesenchymal stem cells: a promising novel exosome exhibiting pro-angiogenic and wound healing effects similar to those of adipose-derived stem cell exosomes.Stem cell research & therapy · 2024Article
- DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.Circulation · 2023Article
- DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization.bioRxiv : the preprint server for biology · 2023Article
- Ablation of endothelialAutophagy · 2023Article
- Downregulation of glycoprotein non-metastatic melanoma protein B prevents high glucose-induced angiogenesis in diabetic retinopathy.Molecular and cellular biochemistry · 2023Article
- ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.Frontiers in oncology · 2023Article
- Identifying General Tumor and Specific Lung Cancer Biomarkers by Transcriptomic Analysis.Biology · 2022Article
- Single-Cell Profiling of Tumor Microenvironment Heterogeneity in Osteosarcoma Identifies a Highly Invasive Subcluster for Predicting Prognosis.Frontiers in oncology · 2022Article
- Study of Single Nucleotide Polymorphisms Associated with Breast Cancer Patients among Arab Ancestries.International journal of breast cancer · 2022Article
- Overexpression of circRNA SNRK targets miR-103-3p to reduce apoptosis and promote cardiac repair through GSK3β/β-catenin pathway in rats with myocardial infarction.Cell death discovery · 2021Article
- Characterization of the prognostic and oncologic values of ITGB superfamily members in pancreatic cancer.Journal of cellular and molecular medicine · 2020Article
- Endothelial deletion of ADAM10, a key regulator of Notch signaling, causes impaired decidualization and reduced fertility in female mice.Angiogenesis · 2020Article
- DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction.Redox biology · 2020Article
- The 3' Untranslated Region Protects the Heart from Angiotensin II-Induced Cardiac Dysfunction via AGGF1 Expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Article
- Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Cardiomyocyte-SpecificJournal of the American Heart Association · 2019Article
- Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue.Molecular metabolism · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Qiulun LuFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Zhonglin XieFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Chenghui YanFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Ye DingFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Zejun MaFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Shengnan WuFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Yu QiuFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Stephanie M CossetteFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Michelle BordasFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee.
Ramani RamchandranFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee. mzou@gsu.edu rramchan@mcw.edu.
Ming-Hui ZouFrom the Center for Molecular and Translational Medicine, Georgia State University, Atlanta (Q.L., Z.X., C.Y., Y.D., Z.M., S.W., Y.Q., M.-H.Z.); and Division of Neonatology, Department of Pediatrics (S.M.C., M.B., R.R.) and Obstetrics and Gynecology (OBGYN), Developmental Vascular Biology Program, Children's Research Institute (R.R.), Medical College of Wisconsin, Milwaukee. mzou@gsu.edu rramchan@mcw.edu.
Georgia State University · US
Funding
Reactive Nitrogen species and Diabetic Endothelial DysfunctionR01HL079584 · NHLBI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ZOU, MING-HUI · 2004 to 2021
$7.3MInflammasome and unstable atherosclerotic plaquesR01HL089920 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2008 to 2022
$6.9MAMP-Activated Protein Kinase in DiabetesR01HL080499 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2006 to 2019
$5.8MControlling VSMC Proliferation and MigrationR01HL110488 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2011 to 2020
$3.9MOxidant stress and diabetic endothelial dysfunctionR01HL074399 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2005 to 2013
$3.2MSNRK in ischemic vascular diseasesR01HL142287 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2018 to 2022
$3.0MFUNDC1 and diabetic cardiomyopathyR01HL137371 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2017 to 2020
$2.8MMKP1, VSMC, and Vascular RemodelingR01HL140954 · NHLBI · GEORGIA STATE UNIVERSITY · PI SONG, PING, ZOU, MING-HUI · 2018 to 2021
$2.8MAutophagy and VSMC migrationR01HL132500 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2016 to 2019
$2.7MSuppression of Autophagy-Dependent Clearance Mitochondria in Type 2 DiabetesR01HL128014 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2015 to 2018
$2.4MLiver kinase B1 in angiogenesisR01CA213022 · NCI · GEORGIA STATE UNIVERSITY · PI ZOU, MING-HUI · 2017 to 2021
$2.3MPrevention of High Fat Diet-Induced Vascular InjuryR01HL105157 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2010 to 2014
$1.8MNCI NIH HHS R01 CA213022NHLBI NIH HHS R01 HL074399NHLBI NIH HHS R01 HL079584NHLBI NIH HHS R01 HL080499NHLBI NIH HHS R01 HL089920NHLBI NIH HHS R01 HL096032NHLBI NIH HHS R01 HL102745NHLBI NIH HHS R01 HL105157NHLBI NIH HHS R01 HL110488NHLBI NIH HHS R01 HL128014NHLBI NIH HHS R01 HL132500NHLBI NIH HHS R01 HL137371NHLBI NIH HHS R01 HL140954NHLBI NIH HHS R01 HL142287NIA NIH HHS R01 AG047776
Abstract
objectiveSNRK (sucrose nonfermenting 1-related kinase) is a novel member of the AMPK (adenosine monophosphate-activated protein kinase)-related superfamily that is activated in the process of angiogenesis. Currently, little is known about the function of SNRK in angiogenesis in the physiological and pathological conditions. APPROACH AND
resultsIn this study, in
conclusionsTaken together, our data have revealed that SNRK/SP1-ITGB1 signaling axis promotes angiogenesis in vivo.
Indexed as
Neovascularization, PhysiologicAnimalsAntigens, CDApoptosisBlood Flow VelocityCadherin 5CadherinsCell MovementCell ProliferationCells, CulturedDisease Models, AnimalEndothelial CellsGene Expression Regulation, EnzymologicHindlimbHumansHuman Umbilical Vein Endothelial CellsAntigens, CDCadherin 5CadherinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIntegrin beta1Protein Serine-Threonine KinasesSNRK protein, humanSnrk protein, mouseSP1 protein, humanSp1 Transcription Factorangiogenesisendothelial cellshindlimbhypoxiaSNRK
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.