Evidence map›Paper›PMID 29242238›Full record

ArticleCirculation research2018

Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis: The Blood-and-Muscle Model.

Athanase Benetos, Simon Toupance, Sylvie Gautier, Carlos Labat, Masayuki Kimura, Pascal M Rossi, Nicla Settembre, Jacques Hubert, Luc Frimat, Baptiste Bertrand and 19 more

Registry-linked trialOpen access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02176941 (Short Telomere in Patients at High Cardiovascular Risk), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02176941 unknown statusnot on this map

Short Telomere in Patients at High Cardiovascular Risk: a Simple Marker or a Major Determinant of Accelerated Arterial Aging

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2014 to 2016Enrolled340ConditionsAtherosclerotic Disease
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Review
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  13. Telomere Length: Implications for Atherogenesis.Current atherosclerosis reports · 2023
    Review
  14. Review
  15. Review
  16. Metabolic regulation of endothelial senescence.Frontiers in cardiovascular medicine · 2023
    Review
  17. Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 4 institutions in 3 countries.

Athanase BenetosFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.). a.benetos@chru-nancy.fr.
Simon ToupanceFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Sylvie GautierFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Carlos LabatFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Masayuki KimuraFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Pascal M RossiFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Nicla SettembreFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Jacques HubertFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Luc FrimatFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Baptiste BertrandFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Mourad BoufiFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Xavier FlecherFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Nicolas SadoulFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Pascal EschwegeFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Michèle KesslerFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Irene P TzanetakouFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Ilias P DoulamisFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Panagiotis KonstantopoulosFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Aspasia TzaniFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Marilina KorouFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Anastasios GkogkosFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Konstantinos PerreasFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Evangelos MenenakosFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Georgios SamanidisFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Michail Vasiloglou-GkanisFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Jeremy D KarkFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Serguei MalikovFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Simon VerhulstFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Abraham AvivFrom the INSERM UMRS 1116 (A.B., S.T., C.L.), Department of Geriatric Medicine, CHRU de Nancy (A.B., S.G.), Department of Vascular Surgery, CHRU de Nancy (N.S., S.M.), Department of Urology, CHRU de Nancy (J.H., P.E.), Department of Nephrology, CHRU de Nancy (L.F., M.K.), and Department of Cardiology, CHRU de Nancy (N.S.), Université de Lorraine, Nancy, France; Center of Human Development and Aging, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark (M.K., A.A.); Department of Internal Medicine, North Hospital, APHM, and UMR-S1076 (P.M.R.) and Department of Plastic Surgery, Conception Hospital, APHM and UMR-S1076 (B.B.), Aix-Marseille University, France; Department of Vascular Surgery (M.B.) and Department of Orthopedic Surgery (X.F.), North Hospital, APHM, Marseille, France; Laboratory for Experimental Surgery and Surgical Research "NS Christeas", National and Kapodistrian University of Athens, Greece (I.P.T., I.P.D., P.K., A.T., M.K., A.G., G.S.); European University of Cyprus, School of Sciences, Engomi (I.P.T.); First Department of Adult Cardiac Surgery, Onassis Cardiac Surgery Center, Athens, Greece (K.P., G.S.); Department of Surgery, Hippokration Hospital and Medical School of Athens, National and Kapodistrian University of Athens, Greece (E.M.); Department of Surgery, Iaso General Hospital, Athens, Greece (M.V.-G.); Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel (J.D.K.); and Groningen Institute for Evolutionary Life Sciences, University of Groningen, The Netherlands (S.V.).
Délégation Centre-Est · FREuropean University Cyprus · CYIASO General Hospital · GRNational and Kapodistrian University of Athens · GR

Funding

Determinants of Leukocyte Telomere Length at BirthR01HD071180 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AVIV, ABRAHAM, FACTOR-LITVAK, PAM R · 2012 to 2016
$3.3M
Leukocyte Telomere Length and Cardiovascular Disease in Jackson Heart StudyR01HL116446 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI AVIV, ABRAHAM, REINER, ALEXANDER P · 2013 to 2016
$3.1M
National Heart, Lung, and Blood Institute R01 HL116446National Institute of Child Health & Human Development R01 HD071180
6 · The paper itself

Abstract

rationaleShort telomere length (TL) in leukocytes is associated with atherosclerotic cardiovascular disease (ASCVD). It is unknown whether this relationship stems from having inherently short leukocyte TL (LTL) at birth or a faster LTL attrition thereafter. LTL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle represents a minimally replicative tissue.

objectiveWe measured LTL and muscle TL (MTL) in the same individuals with a view to obtain comparative metrics for lifelong LTL attrition and learn about the temporal association of LTL with ASCVD. METHODS AND

resultsOur Discovery Cohort comprised 259 individuals aged 63±14 years (mean±SD), undergoing surgery with (n=131) or without (n=128) clinical manifestation of ASCVD. In all subjects, MTL adjusted for muscle biopsy site (MTL

conclusionsThis first study to apply the blood-and-muscle TL model shows more pronounced LTL attrition in ASCVD patients than controls. The difference in LTL attrition was not associated with age during adulthood suggesting that increased attrition in early life is more likely to be a major explanation of the shorter LTL in ASCVD patients. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02176941.

Indexed as

Telomere ShorteningAgedAtherosclerosisFemaleHumansLeukocytesMaleMiddle AgedMuscle Fibers, Skeletalagingatherosclerosisbiopsyleukocytesmuscletelomere

Identifiers

PMID29242238
PMCPMC5821479
OpenAlexW2773519791

What OpenQuestion holds

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