ArticleJournal of cell science2018
Paracrine brassinosteroid signaling at the stem cell niche controls cellular regeneration.
Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Methylome and Transcriptome Analysis Reveals Differences in Callus Development and Plantlet Regeneration Capacity Between TwoPlants (Basel, Switzerland) · 2026Article
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- Out of the Niche: A Bird's-Eye View of the Molecular Networks Controlling Root Stem Cells.Plants (Basel, Switzerland) · 2025Review
- BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19.EMBO reports · 2025Article
- Brassinosteroids en route.Nature chemical biology · 2023Article
- A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Histidine kinase inhibitors impair shoot regeneration inFrontiers in plant science · 2022Article
- Mechanisms of stress response in the root stem cell niche.Journal of experimental botany · 2021Review
- Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis.Nature communications · 2021Article
- Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots.Molecular systems biology · 2021Article
- Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks inScience advances · 2021Article
- Local brassinosteroid biosynthesis enables optimal root growth.Nature plants · 2021Article
- Plant stem cell research is uncovering the secrets of longevity and persistent growth.The Plant journal : for cell and molecular biology · 2021Review
- Roles of Brassinosteroids in Mitigating Heat Stress Damage in Cereal Crops.International journal of molecular sciences · 2021Review
- Development-related mitochondrial properties of retinal pigment epithelium cells derived from hEROs.International journal of ophthalmology · 2021Article
- CLE40 Signaling Regulates Root Stem Cell Fate.Plant physiology · 2020Article
- Brassinosteroid signaling in plant development and adaptation to stress.Development (Cambridge, England) · 2019Review
- Overexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth.Nature communications · 2018Article
- Stem cell-derived mitochondria transplantation: a novel strategy and the challenges for the treatment of tissue injury.Stem cell research & therapy · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell regeneration is crucial for both cell turnover and tissue healing in multicellular organisms. In Arabidopsis roots, a reduced group of cells known as the quiescent center (QC) act as a cell reservoir for surrounding stem cells during both normal growth and in response to external damage. Although cells of the QC have a very low mitotic activity, plant hormones such as brassinosteroids (BRs) can promote QC divisions. Here, we used a tissue-specific strategy to investigate the spatial signaling requirements of BR-mediated QC divisions. We generated stem cell niche-specific receptor knockout lines by placing an artificial microRNA against BRI1 (BRASSINOSTEROID INSENSITIVE 1) under the control of the QC-specific promoter WOX5. Additionally, QC-specific knock-in lines for BRI1 and its downstream transcription factor BES1 (BRI1-EMS-SUPPRESOR1) were also created using the WOX5 promoter. By analyzing the roots of these lines, we show that BES1-mediated signaling cell-autonomously promotes QC divisions, that BRI1 is essential for sensing nearby inputs and triggering QC divisions and that DNA damage promotes BR-dependent paracrine signaling in the stem cell niche as a prerequisite to stem cell replenishment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.