Evidence map›Paper›PMID 29242201›Full record

ArticleCirculation. Cardiovascular genetics2017

Familial Aggregation of Aortic Valvular Stenosis: A Nationwide Study of Sibling Risk.

Andreas Martinsson, Xinjun Li, Bengt Zöller, Pontus Andell, Charlotte Andersson, Kristina Sundquist, J Gustav Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Article
  13. Network-Guided Multiomic Mapping of Aortic Valve Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2023
    Review
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  15. Article
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  17. Article
  18. Risk factors for valvular calcification.Current opinion in endocrinology, diabetes, and obesity · 2019
    Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Andreas MartinssonFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.). andreas.martinsson@med.lu.se.
Xinjun LiFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).
Bengt ZöllerFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).
Pontus AndellFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).
Charlotte AnderssonFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).
Kristina SundquistFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).
J Gustav SmithFrom the Department of Cardiology, Clinical Sciences (A.M., P.A., J.G.S.) and Center for Primary Health Care Research (X.L., B.Z., K.S.), Lund University, Sweden; Skåne University Hospital, Lund, Sweden (A.M., P.A., J.G.S.); Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark (C.A.); and Department of Family Medicine and Community Health and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY (K.S.).

Funding

Neighborhoods and Coronary Disease: Exploring Mechanisms and Improving MethodsR01HL116381 · NHLBI · LUNDS UNIVERSITET · PI SUNDQUIST, KRISTINA · 2014 to 2017
$1.9M
NHLBI NIH HHS R01 HL116381
6 · The paper itself

Abstract

backgroundAortic valvular stenosis (AS) is the most common cause of cardiac valvular replacement surgery. During the last century, the pathogenesis of AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although a familial component has been described for a subset of cases with a bicuspid valve, data are limited on the overall familial aggregation of this disease. METHODS AND

resultsContemporary information on 6 117 263 Swedish siblings, of which 13 442 had a clinical diagnosis of AS, was collected from the nationwide Swedish Multi-Generation Register and the National Patient Register. A total of 4.8% of AS cases had a sibling history of AS. Having at least 1 sibling with AS was associated with a hazard ratio of 3.41 (95% confidence interval, 2.23-5.21) to be diagnosed with AS in an adjusted model. Individuals with >1 sibling with AS had an exceptionally high risk (hazard ratio, 32.84) but were uncommon (34 siblings from 11 sibships). In contrast, spouses of subjects with AS were only slightly more likely to be diagnosed with AS compared with subjects without spousal AS (hazard ratio 1.16 for husbands and 1.18 for wives).

conclusionsA sibling history of clinically diagnosed AS was associated with increased risk of AS. Spouses of patients with AS only had a modest risk increase, suggesting that shared adult environmental factors contribute less to the development of AS than genetic factors.

Indexed as

SiblingsAdultAgedAortic Valve StenosisFamilyFemaleHumansMaleMiddle AgedRisk FactorsSensitivity and SpecificitySpousesYoung Adultaortic valve stenosisrisksiblingsvalvular heart diseases

Identifiers

PMID29242201
PMCPMC5734674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.