ArticleCell reports2017
Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
What it found
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Who cites it
106 citing papers in PubMed, 184 citations in OpenAlex.
- Familial Autonomic Ganglionopathy Caused by RareNeurology · 2021Trial
- CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesia.Chinese medicine · 2026Article
- Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis.Nature neuroscience · 2026Article
- Deep visual proteomics uncovers nociceptor diversity and pain targets.Nature communications · 2026Article
- Article
- Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.Nature reviews. Gastroenterology & hepatology · 2026Review
- Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- FM-dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain.British journal of pharmacology · 2026Article
- Impaired PIEZO1 function drives uterine hypercontractility in adenomyosis-associated dysmenorrhea.Human reproduction open · 2026Article
- Article
- PIEZO channels link mechanical forces to uterine contractions in parturition.Science (New York, N.Y.) · 2025Article
- MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Skin-Brain Axis: neural pathways in acupuncture treatment.Chinese medicine · 2025Review
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Renal interoception: form, function, and open questions.Current opinion in neurobiology · 2025Review
- Ectopic Nociceptor Sprouting as a Key Peripheral Driver of Pain in Rheumatoid Arthritis.Current rheumatology reports · 2025Review
- Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.The Journal of clinical investigation · 2025Article
- Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons.Communications biology · 2025Article
- Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates.eNeuro · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described. Here, we have identified a subset of peptidergic C-fiber nociceptors that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli when exposed to the inflammatory mediator nerve growth factor (NGF). Strikingly, NGF did not affect mechanosensitivity of other nociceptors. We show that these mechanoinsensitive "silent" nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3) and that the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons. Retrograde tracing revealed that CHRNA3
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.