Evidence map›Paper›PMID 29241446›Full record

ReviewGenome medicine2017

Narrowing the spectrum: the new frontier of precision antimicrobials.

Alexandra E Paharik, Henry L Schreiber, Caitlin N Spaulding, Karen W Dodson, Scott J Hultgren

Abstract readReview
In one paragraph

Review in Genome medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. "Antibiotics (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Juglone as a Natural Quorum Sensing Inhibitor againstACS pharmacology & translational science · 2024
    Article
  14. Article
  15. Article
  16. Sequence specificity defines the effectiveness of PPMOs targetingAntimicrobial agents and chemotherapy · 2023
    Article
  17. Article
  18. Article
  19. Pathogen-Targeted Clinical Development to Address Unmet Medical Need: Design, Safety, and Efficacy of the ATTACK Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra E PaharikDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Henry L SchreiberDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Caitlin N SpauldingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Karen W DodsonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. hultgren@wustl.edu.

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
PATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
Delineating the role of inflammation and the microbiota in uropathogenic E. coli intestinal colonizationF31DK107057 · NIDDK · WASHINGTON UNIVERSITY · PI SPAULDING, CAITLIN NICOLE · 2016 to 2017
$46k
NIAID NIH HHS R01 AI048689NIAID NIH HHS R37 AI048689NIDDK NIH HHS F31 DK107057NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406NIH HHS 1F31DK107057NIH HHS P50DK064540NIH HHS R01AI048689NIH HHS RO1DK051406
6 · The paper itself

Abstract

Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.

Indexed as

AnimalsAnti-Infective AgentsBacterial InfectionsGastrointestinal MicrobiomeHumansPrecision MedicineAnti-Infective Agents

Identifiers

PMID29241446
PMCPMC5729598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.