ArticlePsychiatric services (Washington, D.C.)2018
Long-Run Trends in Antidepressant Use Among Youths After the FDA Black Box Warning.
Article in Psychiatric services (Washington, D.C.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Exploring risk signals of association between drugs and suicide: a retrospective investigation from 2004 to 2024.Frontiers in psychiatry · 2026Article
- Age- and Sex-Related Trends in Psychotropic Prescribing Among Youths in Denmark and the United States: 2010-2020.Pharmacoepidemiology and drug safety · 2025Article
- Black Box Warning Did Not Cause Increased Suicides.Psychiatric research and clinical practice · 2021Article
- Response to "Black Box Warning Did Not Cause Increased Suicides".Psychiatric research and clinical practice · 2021Article
- Depression treatment preferences by race/ethnicity and gender and associations between past healthcare discrimination experiences and present preferences in a nationally representative sample.Social science & medicine (1982) · 2020Article
- Duty to Warn: Antidepressant Black Box Suicidality Warning Is Empirically Justified.Frontiers in psychiatry · 2020Review
- Liability and Patient Suicide.Focus (American Psychiatric Publishing) · 2019Article
- Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn October 2004, the Food and Drug Administration directed pharmaceutical companies to issue a black box warning about the potential link between the use of antidepressants and suicidal ideation among children. This study analyzed long-run trends in antidepressant use among children before and after the black box warning for those with and without severe psychological impairment.
methodsThe analysis used data from the Medical Expenditure Panel Survey for children ages five to 17, covering years 2000-2011 (N=75,819). The study used multivariate probit models to compare the changes in the rate of any antidepressant use in the early (2004-2007) and late (2008-2011) postwarning years with the rate in the prewarning years (2002-2003). Recycled predictions methods were used to estimate yearly predicted probabilities of use.
resultsAfter adjustment for all covariates, there was a .5% statistically significant decline in the probability of using any antidepressants during the early postwarning years (2004-2007) compared with prewarning years. In the long run (2008-2011), however, there was no statistically significant difference. Five years after the black box warning, the adjusted rates of use increased to their prewarning levels (2.29% in 2003 and 2.26% in 2009). The initial impact of the warning differed between the severe and nonsevere populations, with a significant effect on those with nonsevere psychological impairment.
conclusionsThe return to the rates before the black box warning raises concern that the impact of the warning may have dissipated over time. More frequent updates of the warning might be necessary.
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