ArticleJournal of intensive care medicine2020
Causes of Mortality in ICU-Acquired Weakness.
Article in Journal of intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Comparative effectiveness of non-pharmacological interventions on health-related quality of life in ICU patients: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit.Journal of pineal research · 2023Trial
- Analysis of the factors related to the knowledge, attitudes, and practices of nurses towards intensive care unit-acquired weakness: a cross-sectional survey.BMC nursing · 2026Article
- An Analysis of Global Research Trends in ICU-Acquired Weakness.Emergency medicine international · 2026Review
- Development and Validation of a Prediction Model for Intensive Care Unit-Acquired Weakness in Adult Patients with Sepsis: A Prospective, Observational, Single-Center Study.International journal of general medicine · 2026Article
- Application of Artificial Intelligence in Physical Rehabilitation of Patients Admitted to the Intensive Care Unit: A Scoping Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Occupational Therapy Intervention for Intensive Care Unit-Acquired Weakness: A Case Report.Cureus · 2025Article
- Review
- Risk factors and predictive nomogram for multi-organ failure in patients with acute kidney failure combined with severe sepsis.American journal of translational research · 2025Article
- The Research Trends and Hotspots of Sepsis and Multiple Organ Failure: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2025Article
- Identification of circulating Tfh/Th subsets as a biomarker of developed hospital-acquired pneumonia.Frontiers in immunology · 2025Article
- Risk factors for ICU-acquired weakness in sepsis patients: A retrospective study of 264 patients.Heliyon · 2024Article
- Significant risk factors for intensive care unit-acquired weakness: A processing strategy based on repeated machine learning.World journal of clinical cases · 2024Article
- PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection.Open life sciences · 2024Article
- Quantification of muscle tone by using shear wave velocity during an anaesthetic induction: a prospective observational study.BMC anesthesiology · 2023Observational
- The association of oral health with length of stay and mortality in the intensive care unit.Clinical oral investigations · 2023Article
- Blockade of Indoleamine 2,3-Dioxygenase attenuates lipopolysaccharide-induced kidney injury by inhibiting TLR4/NF-κB signaling.Clinical and experimental nephrology · 2023Article
- Article
- Effects of early standardized enteral nutrition on preventing acute muscle loss in the acute exacerbation of chronic obstructive pulmonary disease patients with mechanical ventilation.World journal of emergency medicine · 2023Article
- Development and validation of an intensive care unit acquired weakness prediction model: A cohort study.Frontiers in medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and is associated with increased mortality, longer mechanical ventilation and longer hospital stay. Little is known about the causes of mortality in patients with ICU-AW. In this study, we aimed to give an overview of the causes of death in a population diagnosed with ICU-AW during hospital admission.
methodsData from a prospective cohort study in the mixed medical-surgical ICU of the Academic Medical Center in Amsterdam were used. Patients were included when mechanically ventilated for more than 48 hours. Intensive care unit-acquired weakness was defined as a mean medical research council score <4. Baseline data and data on the time of death were collected.
resultsFifty-three patients were included. Irreversible shock with multiple organ failure (MOF) was the most common cause of death (28/53 of patients; 26 patients with septic shock and 2 patients with hypovolemic shock). Most common site of sepsis was abdominal (38.5%) and pulmonary (19.2%). On admission to the ICU, 53% had a do-not-resuscitate code. In 74% of the patients, further treatment limitations were implemented during their ICU stay.
conclusionIn this cohort of patients with ICU-AW, most patients died of irreversible shock with MOF, caused by sepsis.
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