ArticleJournal of the mechanical behavior of biomedical materials2018
A novel use of 3D printing model demonstrates the effects of deteriorated trabecular bone structure on bone stiffness and strength.
Article in Journal of the mechanical behavior of biomedical materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Comparative evaluation of additively manufactured PLA models as cost-effective, non-inferior alternatives to composite bones for pull-out testing.Archives of orthopaedic and trauma surgery · 2026Article
- Compressive Strength Optimization of 3D-Printed Voronoi Trabecular Bone Using the Taguchi Method.Biomimetics (Basel, Switzerland) · 2025Article
- Lead Toxicity and Maternal Exposure: Characterisation of Alveolar Bone Changes on Offspring Rats.Biological trace element research · 2025Article
- Investigation of the mechanical frequency response of ovine renal tissue at low frequencies.Scientific reports · 2025Article
- Application and progress of 3D printed biomaterials in osteoporosis.Frontiers in bioengineering and biotechnology · 2025Review
- 3D bioprinting for the construction of drug testing models-development strategies and regulatory concerns.Frontiers in bioengineering and biotechnology · 2025Review
- Viscoelasticity of ECM and cells-origin, measurement and correlation.Mechanobiology in medicine · 2024Review
- Quantitative Analysis of Primary Compressive Trabeculae Distribution in the Proximal Femur of the Elderly.Orthopaedic surgery · 2024Article
- Cortical and Trabecular Bone Modeling and Implications for Bone Functional Adaptation in the Mammalian Tibia.Bioengineering (Basel, Switzerland) · 2024Review
- Mechanical impact of regional structural deterioration and tissue-level compensation on proximal femur trabecular bone.Frontiers in bioengineering and biotechnology · 2024Article
- Characterization of mechanical stiffness using additive manufacturing and finite element analysis: potential tool for bone health assessment.3D printing in medicine · 2023Article
- Three-Dimensional Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023Review
- A New Microarchitecture-Based Parameter to Predict the Micromechanical Properties of Bone Allografts.Materials (Basel, Switzerland) · 2023Article
- Combined computational analysis and cytology show limited depth osteogenic effect on bone defects in negative pressure wound therapy.Frontiers in bioengineering and biotechnology · 2023Article
- Studying trabecular bone samples demonstrates a power law relation between deteriorated structure and mechanical properties - a study combining 3D printing with the finite element method.Frontiers in endocrinology · 2023Article
- 3D printed trabeculae conditionally reproduce the mechanical properties of the actual trabeculae - A preliminary study.Heliyon · 2022Article
- Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method.Biomedical engineering online · 2022Article
- Comparative Evaluation of Hybrid 3D-Printed Models versus Cadaveric Animal Jaws: A Student's Perspective.Journal of maxillofacial and oral surgery · 2022Article
- Additively manufactured metallic biomaterials.Bioactive materials · 2022Review
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2 authors.
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Abstract
Trabecular bone structure is crucial to normal mechanical behavior of bones. Studies have shown that osteoporosis negatively affects trabecular bone structure, mainly by reducing bone volume fraction (BV/TV) and thus increasing fracture risk. One major limitation in assessing and quantifying the effect of this structural deterioration is that no two trabecular structures are identical. Thus, when we compare a group of healthy bones against a different group of bones that experienced resorption (i.e. decreased BV/TV) we only discover an "average" mechanical effect. It is impossible to quantify the mechanical effect of individual structural deterioration for each sample, simply because we never have the same sample in both states (intact and deteriorated structure). 3D printing is a new technology that can assist in overcoming this issue. Here we report a preliminary study that compares a healthy 3D printed trabecular bone model with the same model after bone resorption was simulated. Since the deteriorated structural bone model is derived from the healthy one, it is possible to directly estimate (percentage wise) the decrease of tissue stiffness and strength as a result of bone resorption for this specific structure. Our results demonstrate that a relatively small decrease in BV/TV (about 8%) leads to a dramatic decrease in structural strength (24%) and structural stiffness (17%), (P < 0.01). Structural strength decreased from an average of 9.14 ± 2.85MPa to 6.97 ± 2.44MPa, while structural stiffness decreased from an average of 282.5 ± 63.4N/mm to 233.8 ± 51.2N/mm. This study demonstrates that 3D printing is a novel and valuable tool for quantifying the effect of structural deterioration on the mechanical properties of trabecular bone. In the future, this approach may help us attain better personal fracture risk assessments by CT scanning, 3D printing and mechanically testing individual bone replicas from patients suffering excessive bone resorption.
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