Evidence map›Paper›PMID 29241036›Full record

ArticleCell host & microbe2017

Plasmodium Peekaboo: PK4 Mediates Parasite Latency.

Edward Rea, Anthony A Holder, Rita Tewari

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Edward ReaSchool of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
Anthony A HolderThe Francis Crick Institute, London, UK.
Rita TewariSchool of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK. Electronic address: rita.tewari@nottingham.ac.uk.
University of Nottingham · GBThe Francis Crick Institute · GB

Funding

Medical Research Council G0900109Medical Research Council G0900278Medical Research Council MR/K011782/1Medical Research Council MR/N023048/1
6 · The paper itself

Abstract

In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

Indexed as

ParasitesPlasmodiumAnimalsAntimalarialsDrug ResistanceEukaryotic Initiation Factor-2MalariaMalaria, FalciparumPhosphorylationPlasmodium falciparumAntimalarialsEukaryotic Initiation Factor-2

Identifiers

PMID29241036
OpenAlexW2775311311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.