ArticleAlcoholism, clinical and experimental research2018
Brief Exposures to the Taste of Ethanol (EtOH) and Quinine Promote Subsequent Acceptance of EtOH in a Paradigm that Minimizes Postingestive Consequences.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Transition From a High-Sugar and Butter to a Standard Diet Leads to Cecal Dysbiosis, Disrupts Intestinal Homeostasis, and Favors Increased Ethanol Consumption and Preference.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.Alcohol, clinical & experimental research · 2024Article
- Prior experience with flavored alcohol increases preference for flavored alcohol but flavor does not influence binge-like drinking behavior in mice.Physiology & behavior · 2023Article
- Intermittent-access operant alcohol self-administration promotes binge-like drinking and drinking despite negative consequences in male and female heterogeneous stock rats.Neuropharmacology · 2023Article
- Article
- Nicotine limits avoidance conditioning with opioids without interfering with the ability to discriminate an opioid-interoceptive state.Pharmacology, biochemistry, and behavior · 2023Article
- Escalation of alcohol intake is associated with regionally decreased insular cortex activity but not changes in taste quality.Alcohol, clinical & experimental research · 2023Article
- An Open-Source Platform for Head-Fixed Operant and Consummatory Behavior.bioRxiv : the preprint server for biology · 2023Article
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex.Scientific reports · 2021Article
- Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms.Frontiers in neuroscience · 2021Article
- Mixtures of Sweeteners and Maltodextrin Enhance Flavor and Intake of Alcohol in Adolescent Rats.Chemical senses · 2020Article
- Altering salivary protein profile can decrease aversive oromotor responding to quinine in rats.Physiology & behavior · 2020Article
- Innate and Acquired Quinine-Resistant Alcohol, but not Saccharin, Drinking in Crossed High-Alcohol-Preferring Mice.Alcoholism, clinical and experimental research · 2019Article
- Nicotine Produces a High-Approach, Low-Avoidance Phenotype in Response to Alcohol-Associated Cues in Male Rats.Alcoholism, clinical and experimental research · 2019Article
- Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.Drug and alcohol dependence · 2019Article
- Postnatal Exposure to Ethanol Increases Its Oral Acceptability to Adolescent Rats.Chemical senses · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAversion to the orosensory properties of concentrated ethanol (EtOH) solutions is often cited as a primary barrier to initiation of drinking and may contribute to abstention. These aversive properties include gustatory processes which encompass both bitter-like taste qualities and trigeminal-mediated irritation. Chronic intermittent EtOH access (CIA) results in substantial and persistent increases in EtOH consumption, but the degree to which this facilitation involves sensory responding to EtOH and other bitter stimuli is currently undetermined.
methodsLong-Evans rats were given brief-access licking tests designed to examine the immediate, taste-guided assessment of the palatability of EtOH and quinine solutions. Rats were assessed once in a naïve state and again following previous brief-access exposure, or following 4 weeks of CIA. The relationship between the sensitivity to the aversive orosensory properties of EtOH and quinine following EtOH access and the impact of antecedent quinine exposure on the acceptance of EtOH were determined in 2 parallel studies.
resultsBoth brief access to EtOH and 4-week CIA resulted in substantial rightward shifts in the concentration-response function of brief-access EtOH licking, indicating that EtOH exposure increased acceptance of the taste of EtOH. The initial sensitivity to the aversive orosensory properties of EtOH and quinine was positively correlated in naïve rats, such that rats that were initially more accepting of quinine were also more accepting of EtOH. Rats that sampled quinine immediately prior to tasting EtOH exhibited successive positive contrast in that they were more accepting of highly concentrated EtOH, relative to a water-control group.
conclusionsIncreased EtOH acceptance following exposure is, at least in part, facilitated by a decrease in its aversive sensory properties. Both long- and short-term access increase the palatability of the taste of EtOH in brief-access licking tests. Moreover, the sensitivity to the bitterness of quinine was predictive of acceptance of EtOH indicating some commonality in the sensory mechanisms that mediate the initial acceptance of the 2 stimuli. Accordingly, immediate prior exposure to quinine results in increased acceptance of EtOH, suggesting that successive positive contrast between oral stimuli may contribute to increased alcohol consumption.
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