ArticlePloS one2017
Vagal nerve stimulation triggers widespread responses and alters large-scale functional connectivity in the rat brain.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- An individual patient data meta-analysis on vagal nerve stimulation for recovery from disorders of consciousness.Scientific reports · 2026Pooled it
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Magnetic Resonance Imaging of Gastric Motility in Conscious Rats.Neurogastroenterology and motility · 2026Article
- Interoception network in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Pairing extinction training with vagus nerve stimulation reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.Frontiers in neuroscience · 2026Article
- Vagus nerve stimulation modulates cocaine seeking induced synaptic plasticity in reward related brain circuits.Scientific reports · 2025Article
- Pairing extinction training with vagus nerve stimulation (VNS) reduces drug-seeking by altering activity in afferents to the medial prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Vagus nerve stimulation modulates synaptic plasticity induced by cocaine- seeking in reward-related circuitry.Research square · 2025Article
- Minimally invasive, wide-field two-photon imaging of the brainstem at cellular resolution.Cell reports methods · 2025Article
- Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.PloS one · 2025Article
- Recent Advancements in Bioelectronic Medicine: A Review.Current drug delivery · 2024Review
- Transcutaneous Auricular Vagus Nerve Stimulation Modulates Performance but Not Pupil Size During Nonnative Speech Category Learning.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins.Biology · 2023Article
- Optimizing the modulation paradigm of transcutaneous auricular vagus nerve stimulation in patients with disorders of consciousness: A prospective exploratory pilot study protocol.Frontiers in neuroscience · 2023Article
- Article
- Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The vagus nerve mediates the stomach-brain coherence in rats.NeuroImage · 2022Article
- Therapeutic Neuromodulation toward a Critical State May Serve as a General Treatment Strategy.Biomedicines · 2022Article
- Acute Vagus Nerve Stimulation Facilitates Short Term Memory and Cognitive Flexibility in Rats.Brain sciences · 2022Article
- Prevention and Treatment of Life-Threatening COVID-19 May Be Possible with Oxygen Treatment.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vagus nerve stimulation (VNS) is a therapy for epilepsy and depression. However, its efficacy varies and its mechanism remains unclear. Prior studies have used functional magnetic resonance imaging (fMRI) to map brain activations with VNS in human brains, but have reported inconsistent findings. The source of inconsistency is likely attributable to the complex temporal characteristics of VNS-evoked fMRI responses that cannot be fully explained by simplified response models in the conventional model-based analysis for activation mapping. To address this issue, we acquired 7-Tesla blood oxygenation level dependent fMRI data from anesthetized Sprague-Dawley rats receiving electrical stimulation at the left cervical vagus nerve. Using spatially independent component analysis, we identified 20 functional brain networks and detected the network-wise activations with VNS in a data-driven manner. Our results showed that VNS activated 15 out of 20 brain networks, and the activated regions covered >76% of the brain volume. The time course of the evoked response was complex and distinct across regions and networks. In addition, VNS altered the strengths and patterns of correlations among brain networks relative to those in the resting state. The most notable changes in network-network interactions were related to the limbic system. Together, such profound and widespread effects of VNS may underlie its unique potential for a wide range of therapeutics to relieve central or peripheral conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.