ArticlePloS one2017
Altered cerebral hemodyamics and cortical thinning in asymptomatic carotid artery stenosis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gray matter asymmetry in asymptomatic carotid stenosis.Human brain mapping · 2021Pooled it
- Lateral Ventricle Enlargement and Cortical Thinning in Idiopathic Normal-pressure Hydrocephalus Patients.Scientific reports · 2018Trial
- A cardiovascular-motor axis framework for perfusion-mediated motor impairment.International journal of cardiology. Heart & vasculature · 2026Review
- Correlation between intravascular pressure gradients and ultrasound velocities in carotid artery stenosis: An exploratory study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Relationship Between Degree of Stenosis and Time-to-Peak Delay in High Grade Asymptomatic Carotid Artery Disease.Stroke · 2026Article
- The pathobiology of neurovascular aging.Neuron · 2025Review
- Distinct cerebral cortical microstructural changes in idiopathic normal-pressure hydrocephalus.Frontiers in neurology · 2025Article
- Intracranial atherosclerotic disease and neurodegeneration: a narrative review and plausible mechanisms.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Review
- Another cause of treatable dementia: rapid cognitive improvement after carotid endarterectomy. Illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Volumetric brain assessment of long-term head and neck cancer survivors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2024Article
- Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis.Frontiers in aging neuroscience · 2024Article
- Improve the diagnosis of idiopathic normal pressure hydrocephalus by combining abnormal cortical thickness and ventricular morphometry.Frontiers in aging neuroscience · 2024Article
- Review
- Intracranial artery stenosis is associated with cortical thinning in stroke-free individuals of two longitudinal cohorts.Journal of the neurological sciences · 2023Article
- Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis.Journal of stroke · 2023Article
- Article
- Neuroimaging anomalies in asymptomatic middle cerebral artery steno-occlusive disease with normal-appearing white matter.Frontiers in neurology · 2023Article
- Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks.Frontiers in aging neuroscience · 2022Article
- Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial.Stroke · 2021Article
- Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease.Clinical neuroradiology · 2021Article
Corrections and comments
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5 authors.
Funding
Abstract
Cortical thinning is a potentially important biomarker, but the pathophysiology in cerebrovascular disease is unknown. We investigated the association between regional cortical blood flow and regional cortical thickness in patients with asymptomatic unilateral high-grade internal carotid artery disease without stroke. Twenty-nine patients underwent high resolution anatomical and single-delay, pseudocontinuous arterial spin labeling magnetic resonance imaging with partial volume correction to assess gray matter baseline flow. Cortical thickness was estimated using Freesurfer software, followed by co-registration onto each patient's cerebral blood flow image space. Paired t-tests assessed regional cerebral blood flow in motor cortex (supplied by the carotid artery) and visual cortex (indirectly supplied by the carotid) on the occluded and unoccluded side. Pearson correlations were calculated between cortical thickness and regional cerebral blood flow, along with age, hypertension, diabetes and white matter hyperintensity volume. Multiple regression and generalized estimating equation were used to predict cortical thickness bilaterally and in each hemisphere separately. Cortical blood flow correlated with thickness in motor cortex bilaterally (p = 0.0002), and in the occluded and unoccluded sides individually; age (p = 0.002) was also a predictor of cortical thickness in the motor cortex. None of the variables predicted cortical thickness in visual cortex. Blood flow was significantly lower on the occluded versus unoccluded side in the motor cortex (p<0.0001) and in the visual cortex (p = 0.018). On average, cortex was thinner on the side of occlusion in motor but not in visual cortex. The association between cortical blood flow and cortical thickness in carotid arterial territory with greater thinning on the side of the carotid occlusion suggests that altered cerebral hemodynamics is a factor in cortical thinning.
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