ArticlePhysics in medicine and biology2017
Fluorescence detection, enumeration and characterization of single circulating cells in vivo: technology, applications and future prospects.
Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Machine learning approach for enumeration of circulating cells with diffuseBiophotonics discovery · 2026Article
- Machine Learning Approach for Enumeration of Circulating Cells with DiffusebioRxiv : the preprint server for biology · 2026Article
- Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review).Oncology reports · 2026Review
- Considerations for the use of targeted fluorescence contrast agents to detect circulating cancer cell populations with diffuseJournal of biomedical optics · 2026Article
- In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38.Molecular imaging and biology · 2024Article
- Two-color diffuseJournal of biomedical optics · 2024Article
- Article
- Dual-ratio approach for detection of point fluorophores in biological tissue.Journal of biomedical optics · 2023Article
- Near-infrared diffuse in vivo flow cytometry.Journal of biomedical optics · 2022Article
- Label-free flow cytometry of rare circulating tumor cell clusters in whole blood.Scientific reports · 2022Article
- Signal and measurement considerations for human translation of diffuse in vivo flow cytometry.Journal of biomedical optics · 2022Article
- Towards rainbow portable Cytophone with laser diodes for global disease diagnostics.Scientific reports · 2022Article
- Prospects for Fluorescence MolecularFrontiers in photonics · 2022Article
- In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells.Light, science & applications · 2021Article
- In Vivo Flow Cytometry.Advances in experimental medicine and biology · 2021Article
- Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry.Molecular imaging and biology · 2020Article
- Time-gated luminescence imaging for background free in vivo tracking of single circulating tumor cells.Optics letters · 2020Article
- Heterogeneity of circulating tumor cell dissemination and lung metastases in a subcutaneous Lewis lung carcinoma model.Biomedical optics express · 2020Article
- Flow-regulated endothelial glycocalyx determines metastatic cancer cell activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Label-free counting of affinity-enriched circulating tumor cells (CTCs) using a thermoplastic micro-Coulter counter (μCC).The Analyst · 2020Article
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4 authors.
Funding
Abstract
There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immunology, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, 'in vivo flow cytometry' (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo. In recent years the IVFC field has grown significantly and new techniques have been developed, including fluorescence microscopy, multi-photon, photo-acoustic, and diffuse fluorescence IVFC. In this paper we review recent technical advances in IVFC, with emphasis on instrumentation, contrast mechanisms, and detection sensitivity. We also describe key applications in biomedical research, including cancer research and immunology. Last, we discuss future directions for IVFC, as well as prospects for broader adoption by the biomedical research community and translation to humans clinically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.