ArticleEuropean journal of haematology2018
Cytochemical flow analysis of intracellular G6PD and aggregate analysis of mosaic G6PD expression.
Article in European journal of haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- G6PD activity patterns and a stable adjusted male median derived from 16 years of clinical laboratory data.Blood research · 2026Article
- Single-Drop Blood Detection of CommonACS omega · 2023Article
- Relationship between Glucose-6-Phosphate Dehydrogenase Deficiency, X-Chromosome Inactivation and Inflammatory Markers.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- G6PD Variants and Haemolytic Sensitivity to Primaquine and Other Drugs.Frontiers in pharmacology · 2021Review
- Article
- Optimizing G6PD testing forWellcome open research · 2020Review
- Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities.International health · 2019Article
- Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.PLoS neglected tropical diseases · 2018Article
- Cytochemical flow analysis of intracellular G6PD and aggregate analysis of mosaic G6PD expression.European journal of haematology · 2018Article
- Point-of-Care Testing for G6PD Deficiency: Opportunities for Screening.International journal of neonatal screening · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 4 countries.
Funding
Abstract
backgroundMedicines that exert oxidative pressure on red blood cells (RBC) can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Due to X-chromosome inactivation, females heterozygous for G6PD with 1 allele encoding a G6PD-deficient protein and the other a normal protein produce 2 RBC populations each expressing exclusively 1 allele. The G6PD mosaic is not captured with routine G6PD tests.
methodsAn open-source software tool for G6PD cytofluorometric data interpretation is described. The tool interprets data in terms of % bright RBC, or cells with normal G6PD activity in specimens collected from 2 geographically and ethnically distinct populations, an African American cohort (USA) and a Karen and Burman ethnic cohort (Thailand) comprising 242 specimens including 89 heterozygous females.
resultsThe tool allowed comparison of data across 2 laboratories and both populations. Hemizygous normal or deficient males and homozygous normal or deficient females cluster at narrow % bright cells with mean values of 96%, or 6% (males) and 97%, or 2% (females), respectively. Heterozygous females show a distribution of 10-85% bright cells and a mean of 50%. The distributions are associated with the severity of the G6PD mutation.
conclusionsConsistent cytofluorometric G6PD analysis facilitates interlaboratory comparison of cellular G6PD profiles and contributes to understanding primaquine-associated hemolytic risk.
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