Evidence map›Paper›PMID 29239858›Full record

ArticlePhysics in medicine and biology2018

Prediction of breast cancer risk using a machine learning approach embedded with a locality preserving projection algorithm.

Morteza Heidari, Abolfazl Zargari Khuzani, Alan B Hollingsworth, Gopichandh Danala, Seyedehnafiseh Mirniaharikandehei, Yuchen Qiu, Hong Liu, Bin Zheng

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  15. Breast Cancer Type Classification Using Machine Learning.Journal of personalized medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Morteza HeidariSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Abolfazl Zargari KhuzaniSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Alan B HollingsworthDepartment of Surgery, Mercy Health Center, Oklahoma City, OK 73120, United States of America.
Gopichandh DanalaSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Seyedehnafiseh MirniaharikandeheiSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Yuchen QiuSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Hong LiuSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
Bin ZhengSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, United States of America.
University of Oklahoma · USMercy Health · US

Funding

Increasing Cancer Detection Yield Using Breast MRI Screening ModalityR01CA197150 · NCI · UNIVERSITY OF OKLAHOMA · PI HOLLINGSWORTH, ALAN B., LIU, HONG · 2015 to 2019
$2.5M
Mammographic Density and Tissue Asymmetry Based Breast Cancer Risk StratificationR01CA160205 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHENG, BIN · 2012 to 2015
$895k
NCI NIH HHS R01 CA160205NCI NIH HHS R01 CA197150
6 · The paper itself

Abstract

In order to automatically identify a set of effective mammographic image features and build an optimal breast cancer risk stratification model, this study aims to investigate advantages of applying a machine learning approach embedded with a locally preserving projection (LPP) based feature combination and regeneration algorithm to predict short-term breast cancer risk. A dataset involving negative mammograms acquired from 500 women was assembled. This dataset was divided into two age-matched classes of 250 high risk cases in which cancer was detected in the next subsequent mammography screening and 250 low risk cases, which remained negative. First, a computer-aided image processing scheme was applied to segment fibro-glandular tissue depicted on mammograms and initially compute 44 features related to the bilateral asymmetry of mammographic tissue density distribution between left and right breasts. Next, a multi-feature fusion based machine learning classifier was built to predict the risk of cancer detection in the next mammography screening. A leave-one-case-out (LOCO) cross-validation method was applied to train and test the machine learning classifier embedded with a LLP algorithm, which generated a new operational vector with 4 features using a maximal variance approach in each LOCO process. Results showed a 9.7% increase in risk prediction accuracy when using this LPP-embedded machine learning approach. An increased trend of adjusted odds ratios was also detected in which odds ratios increased from 1.0 to 11.2. This study demonstrated that applying the LPP algorithm effectively reduced feature dimensionality, and yielded higher and potentially more robust performance in predicting short-term breast cancer risk.

Indexed as

AlgorithmsMachine LearningAdultAgedAged, 80 and overBreastBreast DensityBreast NeoplasmsFemaleHumansImage Processing, Computer-AssistedMammographyMiddle AgedRadiographic Image Interpretation, Computer-AssistedRisk AssessmentYoung Adult

Identifiers

PMID29239858
PMCPMC5801007
OpenAlexW2775577467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.