Evidence map›Paper›PMID 29239725›Full record

ArticleeLife2017

T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.

Tobias X Dong, Shivashankar Othy, Amit Jairaman, Jonathan Skupsky, Angel Zavala, Ian Parker, Joseph L Dynes, Michael D Cahalan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 79 citations in OpenAlex.

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  12. Asymmetric development and function of paired sperm-storage organs inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tobias X Dong *Department of Physiology and Biophysics, University of California, Irvine, United States.ORCID http://orcid.org/0000-0001-5500-7099
Shivashankar Othy *Department of Physiology and Biophysics, University of California, Irvine, United States.ORCID http://orcid.org/0000-0001-6832-5547
Amit JairamanDepartment of Physiology and Biophysics, University of California, Irvine, United States.
Jonathan SkupskyDepartment of Physiology and Biophysics, University of California, Irvine, United States.
Angel ZavalaDepartment of Physiology and Biophysics, University of California, Irvine, United States.
Ian ParkerDepartment of Physiology and Biophysics, University of California, Irvine, United States.
Joseph L DynesDepartment of Physiology and Biophysics, University of California, Irvine, United States.
Michael D CahalanDepartment of Physiology and Biophysics, University of California, Irvine, United States.ORCID http://orcid.org/0000-0002-4987-2526
University of California, Irvine · US

Funding

Molecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0M
Elementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Molecular Mechanisms of Ion Channels in T LymphocytesR37NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2006 to 2012
$3.3M
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5M
Molecular Mechanisms of lon Channels in T LymphocytesR56NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2018 to 2018
$514k
A Transgenic Mouse Line to Map Cell-Type Specific Calcium Signals In VivoR21AI117555 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2015 to 2016
$425k
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER56AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2016
$103k
NCATS NIH HHS TL1 TR001415NIAID NIH HHS R01 AI121945NIAID NIH HHS R21 AI117555NIAID NIH HHS R56 AI121945NIGMS NIH HHS R37 GM048071NINDS NIH HHS R01 NS014609NINDS NIH HHS R37 NS014609NINDS NIH HHS R56 NS014609
6 · The paper itself

Abstract

Calcium is an essential cellular messenger that regulates numerous functions in living organisms. Here, we describe development and characterization of 'Salsa6f', a fusion of GCaMP6f and tdTomato optimized for cell tracking while monitoring cytosolic Ca

Indexed as

Calcium SignalingAnimalsCalciumCalcium ChannelsGenes, ReporterMiceMice, TransgenicOptical ImagingRecombinant Fusion ProteinsT-LymphocytesCalciumCalcium ChannelsRecombinant Fusion ProteinsCa2+ signalingcell biologygenetically encoded Ca2+ indicatorhumanimmunologymouseOrai1T cell motilitytwo-photon microscopy

Identifiers

PMID29239725
PMCPMC5747524
OpenAlexW2766846264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.