ArticleeLife2017
Intermittent Ca
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Orai1 acts as a novel CaExperimental & molecular medicine · 2026Article
- Deriving the A/B Cells Policy as a Robust Multi-Object Cell Pipeline for Time-Lapse Microscopy.International journal of molecular sciences · 2025Article
- Polymorphism-driven immune disruptions in Kawasaki disease across populations: decoding the role of T and B-cells.Frontiers in immunology · 2025Review
- Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics.Science advances · 2024Article
- SESN2 attenuates sevoflurane-induced cognitive impairment and neuroinflammation in rats.Experimental brain research · 2024Article
- Article
- A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023Article
- Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P.iScience · 2023Article
- How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity.Cancers · 2022Review
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Ion channel mediated mechanotransduction in immune cells.Current opinion in solid state & materials science · 2021Article
- Calcium Imaging in T Lymphocytes: a Protocol for Use with Genetically Encoded or Chemical CaBio-protocol · 2021Article
- Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4Science advances · 2021Article
- Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing.Nature communications · 2021Article
- Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KFrontiers in pharmacology · 2021Article
- cAMP Bursts Control T Cell Directionality by Actomyosin Cytoskeleton Remodeling.Frontiers in cell and developmental biology · 2021Article
- CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity.Trends in immunology · 2020Review
- Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta.The Journal of general physiology · 2020Article
- Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo.eLife · 2020Article
- Intramembrane ionic protein-lipid interaction regulates integrin structure and function.PLoS biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Tobias X Dong *Department of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0001-5500-7099
Shivashankar Othy *Department of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID http://orcid.org/0000-0001-6832-5547
Milton L GreenbergDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Amit JairamanDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Chijioke AkunwafoDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Sabrina LeverrierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Ying YuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Ian ParkerDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Joseph L DynesDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Michael D CahalanDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID http://orcid.org/0000-0002-4987-2526
University of California, Irvine · US
Funding
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1MMolecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0MElementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3MTHE ROLE OF ION CHANNELS IN LYMPHOCYTE ACTIVATIONR01GM041514 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1988 to 2013
$5.2MCellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5MImmunology Research Training ProgramT32AI060573 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2005 to 2020
$1.9MA Transgenic Mouse Line to Map Cell-Type Specific Calcium Signals In VivoR21AI117555 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2015 to 2016
$425kNCATS NIH HHS UL1 TR001414NIAID NIH HHS R01 AI121945NIAID NIH HHS R21 AI117555NIAID NIH HHS T32 AI060573NIGMS NIH HHS R01 GM041514NIGMS NIH HHS R37 GM048071NIGMS NIH HHS T32 GM008620NINDS NIH HHS R01 NS014609
Abstract
Ca
Indexed as
Cell MovementSignal TransductionCalciumCells, CulturedHumansLocomotionOptical ImagingORAI1 ProteinStaining and LabelingT-LymphocytesCalciumORAI1 ProteinORAI1 protein, humanCa2+ signalingcell biologycell motilitygenetically encoded Ca2+ indicatorhumanimmunologymouseOrai1two-photon microscopy
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.