Evidence map›Paper›PMID 29239480›Full record

ArticleAnnals of the New York Academy of Sciences2017

Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.

Poojya Anantharam, Elizabeth M Whitley, Belinda Mahama, Dong-Suk Kim, Souvarish Sarkar, Cristina Santana, Adriano Chan, Anumantha G Kanthasamy, Arthi Kanthasamy, Gerry R Boss and 1 more

Open access · greenAbstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Comparison of MSAnalytical and bioanalytical chemistry · 2021
    Article
  9. Article
  10. Midazolam Efficacy Against Acute Hydrogen Sulfide-Induced Mortality and Neurotoxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Poojya AnantharamDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.
Elizabeth M WhitleyPathogenesis, LLC, Gainesville, Florida.
Belinda MahamaDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.
Dong-Suk KimDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.
Souvarish SarkarDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa.
Cristina SantanaDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.
Adriano ChanDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa.
Anumantha G KanthasamyDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa.
Arthi KanthasamyDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa.
Gerry R BossDepartment of Medicine, University of California, San Diego, San Diego, California.
Wilson K RumbeihaDepartment of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa.
Iowa State University · USThermoGenesis (United States) · USUniversity of San Diego · US

Funding

Photonics Monitoring and Modeling CoreU54ES027698 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2016 to 2021
$16.7M
Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
Efficacy of Cobinamide for Treatment of Hydrogen Sulfide-induced NeurotoxicityR21NS089487 · NINDS · IOWA STATE UNIVERSITY · PI RUMBEIHA, WILSON KIIZA · 2014 to 2015
$780k
NIEHS NIH HHS U54 ES027698NINDS NIH HHS R21 NS089487NINDS NIH HHS U01 NS058030NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

AnimalsCobamidesDose-Response Relationship, DrugHydrogen SulfideMaleMental DisordersMice, Inbred C57BLModels, NeurologicalSeizuresSurvival AnalysisTime FactorsTreatment OutcomeVitamin B ComplexWeight LossCobamidescobinamideHydrogen SulfideVitamin B Complexcobinamidehydrogen sulfideneurological sequelaeneuroprotection

Identifiers

PMID29239480
PMCPMC5734662
OpenAlexW2772264690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.