Evidence map›Paper›PMID 29239259›Full record

ArticleThe Journal of international medical research2018

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus.

Manar Al-Lawama, Iyad Alammori, Tariq Abdelghani, Eman Badran

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06601114 (The Effectiveness of Paracetamol Versus Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Neonates), which is not on this map. Cited by 33 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 8 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06601114 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

The Effectiveness of Paracetamol Versus Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Neonates

TypeinterventionalSponsorArooj KhanRan2024 to 2024Enrolled254ConditionsPatent Ductus Arteriosus in Preterm InfantsArmsParacetamol Group, Ibuprofen group
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  9. A randomized trial of intravenous acetaminophen versus indomethacin for treatment of hemodynamically significant PDAs in VLBW infants.Journal of perinatology : official journal of the California Perinatal Association · 2021
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  11. A pilot randomised blinded placebo-controlled trial of paracetamol for later treatment of a patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Manar Al-LawamaPediatric Department, University of Jordan, Jordan University Hospital, Jordan.ORCID http://orcid.org/0000-0001-9313-112X
Iyad AlammoriPediatric Department, University of Jordan, Jordan University Hospital, Jordan.
Tariq AbdelghaniPediatric Department, University of Jordan, Jordan University Hospital, Jordan.
Eman BadranPediatric Department, University of Jordan, Jordan University Hospital, Jordan.
University of Jordan · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

Indexed as

AcetaminophenAdministration, OralAnti-Inflammatory Agents, Non-SteroidalDuctus Arteriosus, PatentEchocardiographyFemaleGestational AgeHumansIbuprofenInfant, Low Birth WeightInfant, NewbornInfant, PrematureMaleRandom AllocationSurvival AnalysisAcetaminophenAnti-Inflammatory Agents, Non-SteroidalIbuprofenibuprofenparacetamolpatent ductus arteriosusPremature infantsrandomized studysafety

Identifiers

PMID29239259
PMCPMC5971505
OpenAlexW2755237105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.