ArticleHuman brain mapping2018
Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Can we predict real-time fMRI neurofeedback learning success from pretraining brain activity?Human brain mapping · 2020Pooled it
- A systematic review of fMRI neurofeedback reporting and effects in clinical populations.NeuroImage. Clinical · 2020Pooled it
- A Guide to Literature Informed Decisions in the Design of Real Time fMRI Neurofeedback Studies: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome.Biological psychiatry · 2020Trial
- Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD.NeuroImage · 2019Trial
- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Interventions for Neural Plasticity in Stroke Recovery.Archives of internal medicine research · 2025Article
- Closed-loop fMRI at the mesoscopic scale of columns and layers: Can we do it and why would we want to?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes.Journal of neurodevelopmental disorders · 2024Article
- Preliminary findings on long-term effects of fMRI neurofeedback training on functional networks involved in sustained attention.Brain and behavior · 2023Article
- Neurofeedback-dependent influence of the ventral striatum using a working memory paradigm targeting the dorsolateral prefrontal cortex.Frontiers in behavioral neuroscience · 2023Article
- Neurofeedback and neural self-regulation: a new perspective based on allostasis.Reviews in the neurosciences · 2022Review
- Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex.Brain sciences · 2021Article
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- Activity or connectivity? A randomized controlled feasibility study evaluating neurofeedback training in Huntington's disease.Brain communications · 2020Article
- Neural substrates of self- and external-preoccupation: A voxel-based morphometry study.Brain and behavior · 2019Article
- Mental Imagery and Brain Regulation-New Links Between Psychotherapy and Neuroscience.Frontiers in psychiatry · 2019Review
- Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and psychiatric conditions. We sought to determine whether real-time fMRI neurofeedback training is feasible in Huntington's disease (HD), and assess any factors that contribute to its effectiveness. In this proof-of-concept study, we used this technique to train 10 patients with HD to volitionally regulate the activity of their supplementary motor area (SMA). We collected detailed behavioral and neuroimaging data before and after training to examine changes of brain function and structure, and cognitive and motor performance. We found that patients overall learned to increase activity of the target region during training with variable effects on cognitive and motor behavior. Improved cognitive and motor performance after training predicted increases in pre-SMA grey matter volume, fMRI activity in the left putamen, and increased SMA-left putamen functional connectivity. Although we did not directly target the putamen and corticostriatal connectivity during neurofeedback training, our results suggest that training the SMA can lead to regulation of associated networks with beneficial effects in behavior. We conclude that neurofeedback training can induce plasticity in patients with Huntington's disease despite the presence of neurodegeneration, and the effects of training a single region may engage other regions and circuits implicated in disease pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.