ArticleThe Laryngoscope2018
Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage.
Article in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025Review
- Analysis of cognitive framework and biomedical translation of tissue engineering in otolaryngology.Scientific reports · 2023Article
- Tissue-engineered vocal fold replacement in swine: Methods for functional and structural analysis.PloS one · 2023Article
- Laryngeal Reconstruction Using Tissue-Engineered Implants in Pigs: A Pilot Study.The Laryngoscope · 2021Article
- A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities.Materials today. Bio · 2021Review
- Tissue engineering of the larynx: A contemporary review.Journal of clinical laboratory analysis · 2021Review
- Coaction of TGF-β1 and CDMP1 in BMSCs-induced laryngeal cartilage repair in rabbits.Journal of materials science. Materials in medicine · 2020Article
- Tissue engineering applications in otolaryngology-The state of translation.Laryngoscope investigative otolaryngology · 2020Review
- Design and biofabrication of dermal regeneration scaffolds: role of oligomeric collagen fibril density and architecture.Regenerative medicine · 2020Article
- Motor endplate-expressing cartilage-muscle implants for reconstruction of a denervated hemilarynx.The Laryngoscope · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectives/hypothesisAdipose-derived mesenchymal stem cells (ASCs) are an exciting potential cell source for tissue engineering because cells can be derived from the simple excision of autologous fat. This study introduces a novel approach for tissue-engineering cartilage from ASCs and a customized collagen oligomer solution, and demonstrates that the resultant cartilage can be used for laryngeal cartilage reconstruction in an animal model. STUDY
designBasic science experimental design.
methodsASCs were isolated from F344 rats, seeded in a customized collagen matrix, and cultured in chondrogenic differentiation medium for 1, 2, and 4 weeks until demonstrating cartilage-like characteristics in vitro. Large laryngeal cartilage defects were created in the F344 rat model, with the engineered cartilage used to replace the cartilage defects, and the rats followed for 1 to 3 months. Staining examined cellular morphology and cartilage-specific features.
resultsIn vitro histological staining revealed rounded chondrocyte-appearing cells evenly residing throughout the customized collagen scaffold, with positive staining for cartilage-specific markers. The cartilage was used to successfully repair large cartilaginous defects in the rat model, with excellent functional results.
conclusionsThis study is the first study to demonstrate, in an animal model, that ASCs cultured in a unique form of collagen oligomer can create functional cartilage-like grafts that can be successfully used for partial laryngeal cartilage replacement. LEVEL OF EVIDENCE: NA. Laryngoscope, 128:E123-E129, 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.